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On tresiba, high after breakfast, low at 3 am, help!

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KathyYC

New Member
Relationship to Diabetes
Type 1
Hi, I'm a newbie to the forum but I've had Type 1 for 47 years. My problem is getting the basal insulin right.
I've been changed from Levemir to Tresiba a month ago (lantus also didn't work).
If my blood sugar is normal at breakfast time, and I have a carb-free breakfast, my sugar goes up to 18 and I feel terrible.
So I'm using my morning novorapid to compensate for that, but I shouldn't have to.

My blood glucose drops every night by 3 am, and comes back up by breakfast time. If it's say 8 before bed, it's 3 by 3 am.
I thought Tresiba would fix this but it's doing the same thing. My Diabetes Nurse Specialist is wonderful but she can't fix it.
Has anyone else had this problem? Would appreciate any suggestions, thank you.
 
For your breakfast - what do you eat? I find if I don’t have carbs with a meal, I need to take some insulin to cover the protein in the meal whereas I can ignore it if I have carbs. I also have to count ‘free’ veg which I wouldn’t normally.

So - even with a carb-free breakfast you might need some insulin.

I have a pump now but previously I’d drop in the night too. I sometimes set an alarm pre-drop and had a small snack. Longterm that’s not a solution but it does stop hypos which are unpleasant at night. If you can’t control the drop, you could ask if you’d qualify for a pump maybe.
 
Protein and fat on their own can cause a spike to it may be what you’re eating. Are you on a Libre to know about the dip? Or do you wake with a hypo? When do you take the tresiba? It might be worth trying swapping it from morning to evening or vice versa.
 
Thanks so much for the replies. I have bran flakes in the morning with milk, no sugar. I wake myself up at 3 am, only while I'm getting used to the new insulin.
I've tried Tresiba in the morning, but have now gone to night, at about midnight when I go to bed. Neither seems to help...
 
Thanks so much for the replies. I have bran flakes in the morning with milk, no sugar. I wake myself up at 3 am, only while I'm getting used to the new insulin.
I've tried Tresiba in the morning, but have now gone to night, at about midnight when I go to bed. Neither seems to help...
have you actually basal tested? I'd do that first and then go from there, it may be that your bolus ratio is off kilter rather than a basal problem xx
 
Thanks so much for the replies. I have bran flakes in the morning with milk, no sugar. I wake myself up at 3 am, only while I'm getting used to the new insulin.
I've tried Tresiba in the morning, but have now gone to night, at about midnight when I go to bed. Neither seems to help...

Apologies for being unclear - I meant what do you have for breakfast when you have a carb-free one and go up to 18 like you described in your opening post?
 
Thanks Kaylz - Yes, I think I've done the DAFNE basal testing i.e. a carb-free lunch - my BG stays more or less the same until before supper. In the morning I have 40g of carbohydrate and 7 units of novorapid. That brings my BG down by lunchtime but it's high until it comes down.
No Inka you weren't unclear. Today I had 2 boiled eggs and my BG went up as I said :-(
Thanks so much for the suggestions everyone.
 
If bran flakes and milk is your low carb breakfast I'm not surprised you go up to 18.
The low through the night is more worrying, less basal will prevent those lows but you need to test all through the day, and tresiba has a long duration so slow changes to dosage.
Benny G, sorry I think I've been unclear. My carb-free breakfast was two eggs, with no novorapid. My normal breakfast is bran flakes with milk, 40g carbohydrate, and I have novorapid 7u to cover it.
 
Ah, eggs. I find I need a small amount of insulin for them and a number of other Type 1 friends do too. I’m not sure how common that is but it’s definitely a thing.

However, your rise was quite large and I’d think there’s either a basal issue or a Waking Rise, which I get. Basically getting up means my blood sugar goes up. This is in addition to the Dawn Phenomenon. If I get up and delay breakfast, my blood sugar will go up. Also, I’m at my most insulin resistant in the morning.

How far in advance of your bran flakes do you bolus? For breakfast I need to bolus a fair way in advance - basically twice as long as before my evening meal. If I don’t do that my blood sugar goes up.

So possibly it’s a combination of things leading to the highs. You do mention that you’ve tried various basal though and if none work for you, perhaps a pump would be the answer.
 
That's interesting. I'll try that tomorrow - doing my insulin as soon as I get up instead of faffing around doing other things for half an hour and doing it just before breakfast.
You may be right about the pump - it's been suggested before but I've been reluctant. Even more so now - the diabetic nurse is only doing telephone appointments. Thanks again for all the support and suggestions - I'm glad I've joined this forum.
 
Move the time of your bolus gradually. So if you normally have it right before eating breakfast, try 10mins, then increase in 5 min increments as needed. Good luck 😉
 
Thanks Kaylz - Yes, I think I've done the DAFNE basal testing i.e. a carb-free lunch - my BG stays more or less the same until before supper. In the morning I have 40g of carbohydrate and 7 units of novorapid. That brings my BG down by lunchtime but it's high until it comes down.
No Inka you weren't unclear. Today I had 2 boiled eggs and my BG went up as I said :-(
Thanks so much for the suggestions everyone.
Hi Kathy,

Sorry to hear you're having these issues. There has been some good comments from the other posts. It's tricky starting new insulins (particularly Tresiba because you have to wait a few days before making any changes and seeing the effects). I too use Tresiba Degludec, 20units each morning for past couple of years. My basal has been very steady throughout the 24hrs of the day.

I hope i'm not trying to tell you things you already know as you have had type 1 for a lot longer than I have but here goes....

You said you "think" you've done basal testing. If you are having the problems you describe, like Kaylz said, first point to start looking is at 24hr basal testing. To get a full picture of the entire day, this needs to be done at more than just lunchtime, it needs to be done at all times of day (not all on same day though) by missing various meals across numerous days. One day do breakfast, another day do lunch etc

You are having problems at 3am and waking.

The 3am hypo is the most important thing to deal with and I'd be dealing with that first before trying to sort the morning issue. It's usually best to only alter one thing at a time (especially with Tresiba). I'd be reducing my basal by just 1 unit. So for me, reducing from 20 units to 19units on Saturday morning at 8am for example, then wait about 48hrs for that change to come through, so about 8am Monday morning. As you probably know, a 1 unit reduction or increase in basal can have a huge affect of blood sugars, so just 1 unit at a time. Then i'd check my 3am blood sugars on Monday night and at waking. Once this is sorted (if it can be) then look at morning rise problem. The problem being, a reduction in basal may sort night time hypo but may lead to constant rises the rest of the day. Ultimately it may well turn out that a pump might be the best solution, but i'd give it a good chance first.

If I've gotten night time sorted then i'd look at the morning rises, I would try skipping breakfast one morning, no food at all. See what happens, by checking blood sugar once an hour, either with finger prick or the libre. See what is happening to my basal levels during that time (is it still rising and by how much? 3mmol or more?), obviously I wouldn't do any exercise during the basal test as that will have an effect on it's own. I usually get a blood glucose rise every morning whether I eat or not and have to take a correction within my breakfast bolus to counter this, which is not an issue. It may be necessary to increase bolus insulin with an extra unit of bolus insulin with the breakfast to counter the rise every morning.

btw, I need to bolus for my breakfast 25mins before breakfast is eaten to prevent a huge spike and I'm also on a much higher ratio at breakfast, more than 1unit for each 10g carbs.
 
Move the time of your bolus gradually. So if you normally have it right before eating breakfast, try 10mins, then increase in 5 min increments as needed. Good luck 😉
I'll do that. Will report back in a few days. x
 
Hi Kathy,

Sorry to hear you're having these issues. There has been some good comments from the other posts. It's tricky starting new insulins (particularly Tresiba because you have to wait a few days before making any changes and seeing the effects). I too use Tresiba Degludec, 20units each morning for past couple of years. My basal has been very steady throughout the 24hrs of the day.
Thanks so much for your reply Amity. There's a lot of interesting info in there. You're right that I need to sort the 3 am dip first, but nothing I do seems to help. I'm already on a pretty low dose of Tresiba, 9u. During the DAFNE course that I did about 8 years ago, the tutors were unable to help - I tried Lantus once a day, Lantus twice a day, Levemir once a day, Levemir twice a day. At present, to avoid a hypo at 3 am, I have to eat carbs and get my blood glucose up before bed. It's very irritating because I'm trying to lose weight but I don't want to drop the Tresiba and lose the good control that I have from lunchtime till bedtime. Sorry to be so negative. I really appreciate the suggestions.
 
Hi Kathy

Excellent advice above.
Like others have mentioned, timing of pre bolus for breakfast can be crucial and for me it needs to be as long as 1 hr before eating breakfast for NovoRapid or 45 mins for Fiasp, plus I usually need an extra 2 units to account for Dawn Phemomenon. Carefully increase your pre bolus timing by 5-10 mins over a period of days to figure out your optimum timing.
I assume you don't have a Freestyle Libre but that may be worth discussing with your team as it will give you so mych more info about what is happening between finger pricks and enable you to make more informed decisions.... for instance, if you had Libre you could inject on a morning and then watch for your BG to start dropping before eating your breakfast.

Out of curiosity, were you using a split dose of Levemir before you went on to Tresiba? I would have thought that a split dose of Levemir would be better in helping you avoid night time hypos as many people need less basal insulin through the night whereas Tresiba gives you a pretty straight line over the 24hr period.
I take half as much Levemir at night as I do in the morning to keep me reasonably in range.... ie 16 units in the morning and 8 at night but those are not spaced 12 hours apart but on waking and going to bed, so about 8am and 11pm. Having the flexibility of varying those doses and the timing of them with Levemir makes it far more fine tuneable in my opinion.
 
Hi Kathy

Excellent advice above.
Like others have mentioned, timing of pre bolus for breakfast can be crucial and for me it needs to be as long as 1 hr before eating breakfast for NovoRapid or 45 mins for Fiasp, plus I usually need an extra 2 units to account for Dawn Phemomenon. Carefully increase your pre bolus timing by 5-10 mins over a period of days to figure out your optimum timing.
I assume you don't have a Freestyle Libre but that may be worth discussing with your team as it will give you so mych more info about what is happening between finger pricks and enable you to make more informed decisions.... for instance, if you had Libre you could inject on a morning and then watch for your BG to start dropping before eating your breakfast.

Out of curiosity, were you using a split dose of Levemir before you went on to Tresiba? I would have thought that a split dose of Levemir would be better in helping you avoid night time hypos as many people need less basal insulin through the night whereas Tresiba gives you a pretty straight line over the 24hr period.
I take half as much Levemir at night as I do in the morning to keep me reasonably in range.... ie 16 units in the morning and 8 at night but those are not spaced 12 hours apart but on waking and going to bed, so about 8am and 11pm. Having the flexibility of varying those doses and the timing of them with Levemir makes it far more fine tuneable in my opinion.
I couldn't agree more about getting the freestyle libre, anybody who is struggling like this has got be a good candidate for getting it.
 
Thanks so much for your reply Amity. There's a lot of interesting info in there. You're right that I need to sort the 3 am dip first, but nothing I do seems to help. I'm already on a pretty low dose of Tresiba, 9u. During the DAFNE course that I did about 8 years ago, the tutors were unable to help - I tried Lantus once a day, Lantus twice a day, Levemir once a day, Levemir twice a day. At present, to avoid a hypo at 3 am, I have to eat carbs and get my blood glucose up before bed. It's very irritating because I'm trying to lose weight but I don't want to drop the Tresiba and lose the good control that I have from lunchtime till bedtime. Sorry to be so negative. I really appreciate the suggestions.
I honestly can't see any negativity in anything you've posted. I really struggled with getting switched onto tresiba. Took ages to get it to the right dose. It's tough, managing type 1. I really think you need a freestyle libre, if only for 6 months. It "speaks" a lot, in terms of information and it can do all the "talking", without having to explain everything to the nurse/doctor.
 
Thank you so much rebrascora and Amity for the advice. I feel very reassured by everyone. I'm going to gradually do my morning novorapid earlier than breakfast. That may well be the problem.
Yes I did try levemir morning and night but unfortunately it didn't help.
Thanks for suggesting freestyle libre. Can you please tell me, what do you do if you do aquarobics or similar which I do (or rather used to do) once a week? Thanks everyone, I'm so glad I posted on this forum.
 
Thank you so much rebrascora and Amity for the advice. I feel very reassured by everyone. I'm going to gradually do my morning novorapid earlier than breakfast. That may well be the problem.
Yes I did try levemir morning and night but unfortunately it didn't help.
Thanks for suggesting freestyle libre. Can you please tell me, what do you do if you do aquarobics or similar which I do (or rather used to do) once a week? Thanks everyone, I'm so glad I posted on this forum.
Hi Kathy,

Well it's funny you should ask that!

Just today I reduced my basal (Tresiba) down a unit from 20 to 19 units. I have finally decided to avoid those occasions when due to exercise I've ended up with rapidly falling background blood sugars and increased sensitivity to my Humalog bolus insulin for the 48hrs after some vigorous exercise. So I've committed to doing regular (daily) exercise. There was no other way to do it for me if on Tresiba Deguldec. You just can't change the dose on the day or afternoon (for split dose insulin users) you decide to do some exercise with Tresiba, which is fine as along as you now that, but it gives me a good reason to commit to regular exercise.

I either do no exercise or do it regularly. I have done some cycling, walking without adjusting both basal and bolus insulin doses, but then there's been times when I exerted myself more than I thought and I end up taking about 60% less short acting insulin for all my meals, and need a snack before bed to keep levels from dropping during the night.

You need to know which phase you are in (e.g within 24-48hrs of doing some vigorous exercise or not Note, gentle exercise won't impact on insulin sensitivity) when you're doing basal tests, because exercise can play havoc with basals and boluses.

So from Sunday at 9am, I will be starting my exercise routine, hopefully my basal reduction of 1 unit will keep background blood sugars level 24hrs and I will then reduce my mealtime boluses of my usual ratios by about 50% too.
 
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