Ascend plus clinical trial

[everydayupsanddowns]

Welcome to the forum @Nimbargent

You may find there are eligibility notes about who can take part in the information pack you were probably sent which might answer your questions about whether your leukaemia will impact your ability to participate.

Most blinded trials are pretty careful to ensure and maintain randomisation, and blinding, partly because participants behaviours can sometimes unwittingly change if they know (or believe they know) which arm they are in.

Best to just take part and see what happens I would suggest. 🙂

 

[Nimbargent]

You may find there are eligibility notes about who can take part in the information pack you were probably sent which might answer your questions about whether your leukaemia will impact your ability to participate.
🙂

Thank you for your kind and rapid response. There is nothing in the notes that helps, except that the study administrators already have access to medical records. I presume that leukaemia would not preclude my participation in the study. Adding another tablet to my daily drug container, whether active or placebo, ought not to be onerous for me.

 

[everydayupsanddowns]

Let us know whether you get invited for the run-in period 🙂

 

[Ph1l]

I knew I was on the placebo as soon as I took the first one - the real drug (as used in the run up) tastes and the placebo doesn’t. And I saw a change for the worse in my blood glucose levels over the next week or so. As it’s looking at the effectiveness of the drug against heart attacks in those who haven’t had before, which IMO is a measurable condition not an opinion, I don’t think it makes any difference to the effectiveness of the trial that the participants know what they’re taking. I don’t think their questionnaire asks anything about how I feel on the drug/placebo - it’s more concerned with if I still take it :-D

 

[Nimbargent]

Let us know whether you get invited for the run-in period 🙂

Thank you again. I will post in due course.

 

[Nimbargent]

I knew I was on the placebo as soon as I took the first one - the real drug (as used in the run up) tastes and the placebo doesn’t.

Thank you. That is most helpful.

 

[Nimbargent]

There has been some contention between my haematologist on one hand and the diabetic nurse and GP on the other. The former prefers a metformin dose of 1g per day, whereas the latter prefers 2g. The haematologist contends that heavy metformin intake may negatively impact eGFR.

Unfortunately, having reduced the metformin, I have seen an increase in HbA1c. The diabetic nurse has increased it again, and I await HbA1c and eGFR results.

The addition of linagliptin to the mix did not improve matters.

I have read that semaglutide tends to improve both HbA1c and eGFR, so the trial may be helpful to me if I am not allocated the placebo.

 

[everydayupsanddowns]

I have read that semaglutide tends to improve both HbA1c and eGFR, so the trial may be helpful to me if I am not allocated the placebo.

Sounds like it would be a handy way to try it out, then be able to discuss any positive impact from it with your GP to make a case for using it longer term?