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Ascend plus clinical trial

I have heard back from AscendPlus as follows:
Ascend Plus is a UK-wide clinical trial testing to see if semaglutide may help protect against heart attacks, strokes and circulatory problems in individuals with Type 2 diabetes.

1) In some individuals, weight loss is a side effect they can experience so you should consider this particularly if you are already of low weight and low BMI.
2) Your blood sugar levels should continue to be monitored by your GP and the trial will not monitor these.
3) Taking sitagliptin should not impact your participation in the trial.

I'll now ponder if it is worth starting the trial...I suppose if I get the placebo I should have no side effects, and if I get the drug and it causes weight loss, I can stop...
 
I have been invited to this study as well but it does say that some people will have the study drug some will have placebo. I don’t think I will qualify for the study as I am 11 and half stone. I am not doing the trial as I need to go on more medication which is the same as the trial med, not overweight by much and need the meds cause having trouble with high blood sugars and I don’t want placebo. I use to work as a clinical research nurse doing first in to man drug trials, I would do trials to further research treatment usually but sadly not this time.
 
I signed up for it last summer and did the run in (3mg Semiglutide for 4 weeks then 7mg for 8 weeks) and am now on the placebo. My understanding from the literature is that if your GP thinks you need semiglutide at any point, then you’d just opt out of the study. I figured there was nothing to loose by volunteering as I’d be no worse off on the placebo and if I’d been picked for the live tablets then there was a potential gain in protection against heart attack/stroke - my father died at 54 from a heart attack caused by undiagnosed T2 so I had an extra driver.
I didn’t realise until I went onto the main trial and the placebo that I had felt slightly off when on the 7mg and even though my low-ish carb diet is very boring, it was nice to feel hungry and look forward to food again LOL
For whoever thought they were maybe too light - I was around the top end of normal BMI when I joined the scheme - maybe that was a factor in me ending up on the placebo - who knows how the ‘randomisation’ works!
You can opt out at any point
 
I rejected my invite to the trial as I am no medication and didn't relish having potentially if it was not placebo to take something I didn't need as my HbA1C is normal and maintained by diet only.
 
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