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Report of Prof. Roy Taylor in mainstream newspaper:

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TinaD said:
https://www.theguardian.com/society...ns-they-wore-aged-21-risk-developing-diabetes Oh well just one size of go then! I think I will print it out and frame it for all those interfering, unqualified, imbeciles who say "You don't need to lose any more weight."
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Cool! Early look at some results from the ReTUNE study.

A bit more detail in this: https://www.eurekalert.org/news-releases/929487

Professor Taylor says: “These results, while preliminary, demonstrate very clearly that diabetes is not caused by obesity but by being too heavy for your own body. It’s due to having too much fat in your liver and pancreas, whatever your BMI.

“In the liver, this excess fat prevents insulin from working normally. In the pancreas, it causes the beta cells to stop producing insulin.

Dr Ahmad Al-Mrabeh, the study’s first author and co-investigator, who has recently moved from Newcastle University to the University of Edinburgh, adds: “We’ve already shown a process called hepatic lipoprotein export to be key.

“Lipoproteins are substances made of protein and fat which export fat through the bloodstream. Excess fat is normally stored in the subcutaneous fat areas under our skin. However, when the stores are filled up, or became dysfunctional, excess fat will spill over into the bloodstream before being stored in the liver and exported by lipoproteins to other tissues.

“We’ve demonstrated that this process is the driver of the fat build-up in the pancreas believed to damage the insulin-producing cells and cause type 2 diabetes.

“Weight loss by calorie restriction is powerful in achieving remission of type 2 diabetes and it is remarkable to have 67% remission in this non-obese group.

"However, this approach is challenging for many people including those with normal BMI. Our team here in Edinburgh is exploring the exact mechanisms that lead to remission during weight loss, which we believe will inform prevention, as well as the design of more targeted novel therapies both in addition to and as alternatives to calorie restriction.”

Professor Taylor adds: “As a rule of thumb, your waist size should be the same now as when you were 21. If you can’t get into the same size trousers now, you are carrying too much fat and therefore at risk of developing type 2 diabetes, even if you aren’t overweight.”
 
Bruce Stephens said:
What does it mean if you can't remember what size jeans you wore when you were 21 🙂
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I know, right? That was exactly my thought. But then again I can never remember my shoe size.
 
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The full piece from Diabetologia: https://link.springer.com/article/10.1007/s00125-021-05519-y

Intra-organ fat content during weight loss-induced remission of type 2 diabetes in people with normal or raised BMI

R. Taylor1, A.C. Barnes1, K.M. Irvine1, T.L. Kelly1, K.G. Hollingsworth1, N. Sattar2, M.E.J. Lean3, A. Al-Mrabeh1;

1Institute of Translational & Clinical Research, Newcastle University, Newcastle upon Tyne, 2Institute of Health and Wellbeing, Glasgow University, Glasgow, 3Human Nutrition, Glasgow University, Glasgow, UK.

Background and aims: The aetiology of type 2 diabetes is often assumed to be different in people who are overweight or obese compared with those with BMI in the ‘normal’ range. However, clinical observation suggested that losing body fat from above a ‘personal fat threshold’ at any BMI level can bring about remission of diabetes. We therefore compared baseline liver and pancreas fat content in people with type 2 diabetes and BMI above or below 27kg/m2 and examined changes in intra-organ fat after weight loss in relation to remission of diabetes in each group.

Materials and methods: We examined data from two cohorts (DiRECT: BMI 35.1±4.5 kg/m2; n=56, age 53.3±7.6 years, diabetes duration 3.0±1.7years; ReTUNE: BMI 24.3±2.0kg/m2, n=17, age 58.2±7.3 years, diabetes duration 2.6±2.2 years). Age, sex and BMI-matched control groups without diabetes were also studied (BMI>27kg/m2: n=18, age 55.4±6.0 years; BMI<27kg/m2: n=11, age 58.8±9.5 years). Weight loss was achieved using a low calorie diet (~800 kcal/day) followed by food reintroduction and weight maintenance. In those with BMI<27kg/m2, other types of diabetes identified by antibody and genetic tests (n=2: 1 T1DM, 1 MODY) were excluded from analysis. Intra-organ fat was quantified by 3-point Dixon magnetic resonance.

Results: In each BMI category, liver and intrapancreatic fat content were higher in diabetes compared with non-diabetic controls. For BMI>27kg/m2: liver fat was 16±1.3 vs. 5.5±1.4% p<0.0001 for type 2 diabetes vs. control respectively, and intrapancreatic fat 8.5±0.3 vs. 6.8±0.5% p<0.010, respectively. For BMI<27kg/m2: liver fat was 4.7±0.8 vs. 1.9±0.3% p=0.016 for type 2 diabetes vs. control, and intrapancreatic fat 5.0±0.3 vs. 3.4±1.1%, p=0.029, respectively. Both diabetic and control groups with BMI >27kg/m2 had significantly higher liver and intrapancreatic fat than those with <27kg/m2 (p<0.0001). After weight loss, liver fat content fell significantly in both groups (BMI>27kg/m2: to 3.0 ±0.5%, p<0.0001; BMI<27: to 1.4±0.1%, p=0.004). Similarly, intrapancreatic fat decreased (BMI>27- to 7.6±0.3%, p<0.0001; BMI <27 to 4.5±0.6%, p=0.026). Diabetes remissions were similar between BMI groups (60% and 67%).

Conclusion: Intra-organ fat content is elevated in people with type 2 diabetes at any level of BMI. Irrespective of BMI, 10-15% weight loss decreased liver and intrapancreatic fat with notably similar rates of remission of type 2 diabetes, consistent with the twin cycle hypothesis. Lesser elevation of liver fat, below the diagnostic threshold for NAFLD, can cause metabolic problems in leaner individuals, indicating the need to develop BMI-specific normal ranges. Across the range of BMIs, early type 2 diabetes has the same reversible pathophysiology.

Clinical Trial Registration Number: ISRCTN15177113

Supported by: We are grateful to Diabetes UK for grant funding

Disclosure: R. Taylor: Grants; Supported by grants from Diabetes UK. Lecture/other fees; academic lectures funded by Novo Nordisk, Lilly and Janssen. Non-financial support; RT is author of book 'Life Without Diabetes'.
 
Makes you wonder why ND isn't mentioned more in press & diabetes circles, would be route for me in different circumstances.
 
Yes, I had read the research papers - what I was astounded by was that a mainstream paper had reported it! Hopefully it will now get out to more people who do not spend their time searching google scholar.
 
I didn't own a pair of jeans until they started selling those with the embroidery on the back pockets, my pair were light blue, gently flared, with a big colourful parrot embroidered. I was well in my 20s by then. I did own a pair of heavy black crepe flares - but couldn't wear any such thing to work during the week, as I worked in an office.

Both were size 12 and no I wouldn't get into them now 50 years later - but there again there is no chance whatsoever of me developing Type 2 diabetes anyway.

@nonethewiser - what is ND ?
 
Bruce Stephens said:
What does it mean if you can't remember what size jeans you wore when you were 21 🙂
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Or more likely for women, dress sizes have changed.
I think my jeans are the same actual size as they were when I was 21 but the size written on them is 4 sizes smaller.
 
Yup for me its true and yes I now fit in my old jeans incredibly. Why on earth did I keep them?

Its a great message. Great that its been reported mainstream.
 
TinaD said:
Yes, I had read the research papers - what I was astounded by was that a mainstream paper had reported it! Hopefully it will now get out to more people who do not spend their time searching google scholar.
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I think this is the first reported data from the ReTUNE trial - ie, the non-obese folllow-up to the original obese DiRECT trial.

In some ways, ReTUNE is more interesting - just because losing weight has been a standard recommendtion for obese/overweight T2D's forever, but until now not for normal weight T2D's.

Anyway, FWIW, if you look back you'll see that Taylor's stuff has been reported in the mainstream press quite frequently.
 
Eddy Edson said:
I think this is the first reported data from the ReTUNE trial - ie, the non-obese folllow-up to the original obese DiRECT trial.

In some ways, ReTUNE is more interesting - just because losing weight has been a standard recommendtion for obese/overweight T2D's forever, but until now not for normal weight T2D's.

Anyway, FWIW, if you look back you'll see that Taylor's stuff has been reported in the mainstream press quite frequently.
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I am glad to hear that. I had not spotted any reference in mainstream to the normal weight/go back to age 21 stuff. It doesn't seem to have made much impact judging by the innumerable instances of unsolicited advice about not needing to lose any more! The more the message is spread the better the chance of saving the NHS a shed load of dosh and newly diagnosed people from feeling hopeless.
 
Thank goodness I’m not type 2 then. It’s a long time since I was 21, I was probably wearing a pair of pink brushed cotton loons ( youngsters, Google them) with Slade embroidered on the back pocket. All done with my own fair hands! Unfortunately, I never kept them. I wonder why? Oh yes I do, I dumped Slade for Duran Duran and didn’t have enough space to embroider their name on my other pocket! 😛
 
TinaD said:
Interesting - do your qualifications, research trials etc exceed those of Prof. Taylor ?
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The apparent failure of Taylor to put T2 into its genetic context is one of the big holes in his theories ( there are others such his seeming dismissal of Insulin Resistance and the Metabolic Syndrome). To be Type 2 Diabetic you need a mix of the dozen or so genes that predispose to it. We used to hear in the late 1990s that the genes for Type 2 were probably beneficial genes in prehistory, that T2s would keep bgs higher and so survive a famine better and that's why the genes predisposing to T2 have been so well preserved and passed on. Not heard about that for ages though.
 
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The researchers at Exeter have identified many differnt types of Diabetes requiring differing regimes.
 
nonethewiser said:
Makes you wonder why ND isn't mentioned more in press & diabetes circles, would be route for me in different circumstances.
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When I achieved remission, waaaaay back, Professor Tylor's work was really just emerging and viewed with a decent dollop of scepticism in most quarters.

On my way to remission, I did lose weight, but really that was more about getting rid of the love handles than some of the significant losses by others. Being the curious sort, I wrote to Professor Taylor to pose a few queries, surrounding remission, in particular relating to his protocols (which I had not followed. I adopted a reduced carb way of eating) maintenance and potential longer term better health.

His response (paraphrased, obviously)was that he was unconcerned how individuals lost their weight. It was the reduction in visceral fat, and the continued maintenance of that which mattered.
 
AndBreathe said:
When I achieved remission, waaaaay back, Professor Tylor's work was really just emerging and viewed with a decent dollop of scepticism in most quarters.

On my way to remission, I did lose weight, but really that was more about getting rid of the love handles than some of the significant losses by others. Being the curious sort, I wrote to Professor Taylor to pose a few queries, surrounding remission, in particular relating to his protocols (which I had not followed. I adopted a reduced carb way of eating) maintenance and potential longer term better health.

His response (paraphrased, obviously)was that he was unconcerned how individuals lost their weight. It was the reduction in visceral fat, and the continued maintenance of that which mattered.
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That makes sense but the Prof's problem is that he talks about Calories which are not a good measure and based on weak science when he should talk about Carbs.
 
Ta
DaveB said:
That makes sense but the Prof's problem is that he talks about Calories which are not a good measure and based on weak science when he should talk about Carbs.
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Taylor isn't interested in low carb. He sticks a fairly standard nutritional balance in his Crash Diet of 800 cals - 50% carbs, 35% fats and 15% protein. In his maintenance diet carbs rise to 53%. It's Similar to the traditional advice of the NHS and DiabetesUk- 45 to 60% of cals from carbs depending on activity and job done, upto 35% from fats and 10-20% from protein.
 
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