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Toujeo 300 unit/ml

M

MBuck

New Member
Relationship to Diabetes
Type 2
I was prescribed Toujeo 300 unit/ml recently to replace Lantus. My bedtime does is 24 units (36 ml). The result is not satisfactory. I'd welcome any comments from those who are using this long acting insulin. Thank you.
 
For my part, the switch from Lantus to Toujeo was a significant improvement. It did take me a few tries to get the dosage right. I was taking 18 units of Lantus. For Toujeo I had to reduce the dosage to 15 units.

Using Lantus, I found that after about 20 hours my blood sugar started to rise, regardless of what I had previously eaten. Toujeo has a different activity profile such that it remains effective for the entire 24 hours of each day.

Remember that it takes 2-3 days for a change in dosage to take effect, so you need to be patient while working to find the correct dosage for you.

Hope this helps…
 
MBuck said:
I was prescribed Toujeo 300 unit/ml recently to replace Lantus. My bedtime does is 24 units (36 ml). The result is not satisfactory. I'd welcome any comments from those who are using this long acting insulin. Thank you.
Click to expand...

I’m not sure I understand your reference to 36ml @MBuck ?

In u300 insulins (more concentrated than the standard u100 strength) there are 300 units for every 1ml.

So 36ml would contain 36x300 =10,800 units?
 
I used to inject 24 units Lantus but when changed to Toujeo I also inject 24 units. In theory I should inject fewer units because 1 unit of Toujeo has 1.5ml insulin while 1 unit of Lantus contains 1 ml of insulin. I am injecting more insulin than before, and I have been using Toujeo for a few months now. The result is not satisfactory.
 
What is not satisfactory about the result? The fact you have to take a little more or are your BG numbers not as good on it?
 
MBuck said:
I used to inject 24 units Lantus but when changed to Toujeo I also inject 24 units. In theory I should inject fewer units because 1 unit of Toujeo has 1.5ml insulin while 1 unit of Lantus contains 1 ml of insulin. I am injecting more insulin than before, and I have been using Toujeo for a few months now. The result is not satisfactory.
Click to expand...
But a unit of Toujeo is equal to a unit of Lantus, or any other insulin. It’s just dissolved in less liquid. All units are the same, in terms of how much insulin there is in them?
 
It's the efficacy of the insulin for my condition. My BG stays horizontally above the acceptable range.
 
MBuck said:
It's the efficacy of the insulin for my condition. My BG stays horizontally above the acceptable range.
Click to expand...

It sounds like you might need a little more Toujeo then @MBuck Can you phone your nurse for advice regarding this?

What would an average day’s food look like for you? Perhaps you could also ask your nurse to look over your diet?

What was your most recent hba1? How much above range is your blood sugar when you test it at home?
 
dannybgoode said:
Experiment with a higher dose in that case to keep things in range?
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I have tried but no improvement. I must say that I have a rare condition and am resistant to insulin. I seeked advise in this forum before but couldn't get a definite solution. Apparently insulin resistance has so far no definite solution available in the medical world.
 
MBuck said:
I was prescribed Toujeo 300 unit/ml recently to replace Lantus. My bedtime does is 24 units (36 ml). The result is not satisfactory. I'd welcome any comments from those who are using this long acting insulin. Thank you.
Click to expand...
24 units is not 36 ml. It’s 24 units, even if it’s a 300u/ml insulin the pen delivers the dose you dial up.
 
MBuck said:
I used to inject 24 units Lantus but when changed to Toujeo I also inject 24 units. In theory I should inject fewer units because 1 unit of Toujeo has 1.5ml insulin while 1 unit of Lantus contains 1 ml of insulin.
Click to expand...
You’ve totally misunderstood there. 1unit of toujeo has nowhere near 1.5ml of insulin. 1.5ml of a 300u/ml insulin would be 450 units. Unless you are drawing up with a syringe the strength is of no relevance whatsoever, you take 24u of toujeo whilst is exactly the same dose as 24u of Lantus.
 
MBuck said:
I have tried but no improvement. I must say that I have a rare condition and am resistant to insulin. I seeked advise in this forum before but couldn't get a definite solution. Apparently insulin resistance has so far no definite solution available in the medical world.
Click to expand...

Looking back at your earlier posts, you mention you developed diabetes after steroid use. You also mention using a fast/meal insulin. Are you still using that? If so, which fast/meal insulin are you using?

Are you happy to say what rare condition you have?
 
If your levels stay reasonably horizontal then the dose of basal insulin (Toujeo) is probably about right but you just need a correction dose of fast acting insulin to bring you down into range where the Toujeo can then keep you level and in range. That is how I see it.
 
The Toujeo needs to be at the correct dose to keep @MBuck level and in range. If I reduced all my pump basal rates by, say, 30% hour by hour, I’d stay level but would run high (because I wouldn’t be having enough basal insulin).
 
MBuck said:
I used to inject 24 units Lantus but when changed to Toujeo I also inject 24 units. In theory I should inject fewer units because 1 unit of Toujeo has 1.5ml insulin while 1 unit of Lantus contains 1 ml of insulin. I am injecting more insulin than before, and I have been using Toujeo for a few months now. The result is not satisfactory.
Click to expand...

Ah! OK. I think I understand the mix-up. Toujeo u300 is more concentrated than Lantus u100, but the expression of ‘units’ of insulin intends to avoid confusion by not talking about doses in ml. Your 24u dose of Toujeo will have as many units of insulin as your 24u dose of Lantus, but will be 1/3 the volume in ml. You are injecting less fluid of Toujeo, to get the same number of units.

That said, it’s not uncommon for people with diabetes to find when switching insulins that their doses may need to change slightly from one insulin to the other.

It sounds as though your Toujeo dose may need adjusting.

For reassurance, 24u of insulin over 24hours doesn’t suggest a high degree of insulin resistance. Some former members needed doses in the 100s of units. And at that point a more concentrated insulin can help with volume of fluid required, and efficient absorption.
 
Thank you so much for everyone's advice and support. I am grateful for your kindness and your time in sharing experiences managing your insulin doses.

We are all different, our reaction to treatment differ too. I'm in a rare illness catalogue that more insulin does I inject the higher glucose level. Raising glucose levels is a side effect from my immunosuppression medicine too. Honestly, my diabetic team is struggling with my condition, not to mention that many medics have hardly ever heard of my condition.

I think this forum is doing a great job providing support and comfort for DM patients. We are warriors. Keep going on folks! All the best. xx
 
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