Switching to Toujeo

[Sprogladite]

I have done a lot of reading about Toujeo and the biggest difference I have found are studies showing that Toujeo has a much slower release than Lantus. Excerpt from one such study below:

In a euglycemic clamp study of patients with type 1 diabetes1 Toujeo® had a slow release for long-lasting action. At steady state, the 24 hour glucose lowering effect (GIR-AUC0-24) of Toujeo® 0.4U/kg was approximately 27% lower with a different distribution profile than that of an equivalent dose of Lantus® Steady-state insulin levels are reached by at least 5 days of once-daily injections with Toujeo® with a gradual release of insulin

This correlated to the results I have been having - everything was exactly the same as Lantus for the first 5 days, and from night 6 I have been consistently much flatter, less peaks in BG (in both directions) and much flatter overnight. Although I had a hypo this morning, it didn't happen until much later than it would have with Lantus. This is why I feel it is worth sticking with for a little longer. I can't argue with the fact I had consistent levels for the entire day yesterday and the previous night - for the first time in I don't know how long! If there is any chance at all that this is what I need, I have to give it a fair chance. I am not listening to anything the DSN says, in fact I have had no contact with her since she suggested lowering the dose (which I haven't done anyway). I would much rather look at the results of studies done on Toujeo and see how that relates to my personal experiences.

 

[Sprogladite]

Toujeo night 8: I did 23 units again last night and was very steady in the 8s all night - and no hypos! I was 6.7 on waking and 7.1 now I've got to work...very pleased with how the last 2 days have gone and also very surprised! 🙂

 

[Sprogladite]

Toujeo night 9: Again did 23 units, and no hypos again 🙂 was in the 8s all night, woke up to 7.7. If I can just find a way to cut out these morning spikes by the time I've got to work then I would have a completely flat line on the libre during the day. Once I make it to 3 or 4 nights of no hypos I'm going to stop getting up at 3am to test my sugars. Fingers crossed!

 

[Sprogladite]

Toujeo nights 10, 11 and 12: things went a bit haywire over the weekend (I think because of the heat) - now back in an air conditioned office but feeling 'off' - even though BGs are within range. Had hypos on Friday and Saturday night. Went really, really high Saturday afternoon whilst walking through the Suffolk countryside with the family, but came down with correction for dinner. Yesterday in particular was weird, it was like the carbs I was eating weren't hitting my system at all - maybe need to rethink my ratios while it's this hot. Saying that there was no hypo last night. Luckily I was swiping the libre every 10 mins in the day to keep an eye on things and managed to avoid any hypos. The joys 🙄

 

[Sprogladite]

Toujeo night 13: things were ok, relatively stable until around 3am where I started dropping (4.4) so had a biscuit (as I was up anyway to check). No hypo as a result, and finding if I inject as soon as I get to work in the mornings then I am able to reduce the morning spike by quite a lot. Have managed to keep it under 10 for the first time in forever today and now sitting at 6.8 two hours after breakfast, so I'll take that. Libre graph is nice and level for today so far. Considering trying the reduced dosage at night and seeing how that goes now my levels are stable in the day. Just a little reluctant to tinker with it while it's so hot out as I never quite know how the diabetes is going to react lol 🙄 We shall see, I'm pretty much making this up as I go along and listening to my instincts at this point lol 🙂

 

[Sprogladite]

Toujeo night 14: I cut my dose to 22 last night...and no hypo 🙂 woke up to 7.5, happy with that. Will be interesting to see what my levels do during the day.