Some results from SAMSON on statin side-effects

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It took me over two years to recover from taking statins, these results mean nothing.
My symptoms included being unable to remember my songs - nothing imaginary about that.
Parts of my memory are still coming back - I am remembering reading books again - bit of a pain really I enjoyed rediscovering books I could almost recite from memory before those few weeks taking the Atorvastatin and Metformin.
It took months, and hours of repeating before I could sing from memory.
 
Bruce Stephens said:
https://twitter.com/x/status/1327999800952971264
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Kind of wonder how robust the study design was, when they had to change the statistical analysis methodology post facto:

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You can get a sense of that from:

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At the median, subjects reported less severe side-effect probs on statins, versus placebo.(But the IQR is so wide I don't know if there's a meaningful signal.)

Really, given the small size of the study, I wonder whether it was actually powered to be very informative at all.

It doesn't seem that there was anything much in it to strngly suggest that subjects were seeing anything other than a nocebo effect ...

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Eddy Edson said:
Really, given the small size of the study, I wonder whether it was actually powered to be very informative at all.

It doesn't seem that there was anything much in it to strngly suggest that subjects were seeing anything other than a nocebo effect ...
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Yes, the small size is disappointing. But in the abstract the design is elegant, I think: give people 12 bottles (4 each of statins, placebo, empty) and have them use them in a predetermined random order.

With enough funding (which ought to be pretty low) it could be expanded greatly. (And maybe that's the idea. I don't get the impression that the study has stopped.)
 
But they are assuming that as soon as you stop taking the statin the unpleasant effects go away instantly. Didn't work like that for me.
 
Drummer said:
But they are assuming that as soon as you stop taking the statin the unpleasant effects go away instantly. Didn't work like that for me.
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I think the assumption is that given a month of something different most people would get the difference. I agree it's quite possible there'll be exceptions so this might well miss some problems, but it matches what most people say, I think: that quite quickly after stopping taking them they feel the problems easing.
 
For me the last painful muscle finally normalized at 18 months. Yes there was some improvement fairly soon after stopping the tablets, but it was not instant.
 
This was all over news yesterday,

Really interesting Nocebo effect, happens with most prescribed drugs I'd imagine, consultant did mention this before commencing statin.
 
I`m with @Drummer on this one I have tried three different types all the same the last lot
nearly killed me, I`ve spoken with Eddy on this subject before and I know plenty of people
who take them daily with no side affects but not for me. Put as many figures as you like out
if you are in the minority that are affected figures don`t really matter.
 
I was offered a different statin and even a different type of drug entirely, by a nurse - I just asked, 'if you'd spent a week feeling suicidal and a year relearning 300 songs you used to have memorised, would you want to risk going through that all over again for something with no obvious benefit?'
It has not been mentioned since.
 
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