It works!!!!
I got an email back from One Touch technical support and it's all sorted. Have to say, once again, I am so impressed with their customer service, so friendly and helpful.
I know a few other have had similar problems so please excuse the long post but I thought I'd let you know what they suggested:
1) Check in your System Properties, within your Control Panel, whether your system is a 64 bit or a 32 bit computer. If it is a 64 bit system, then the USB driver is not currently compatible and we are working on an upgrade. If this is the case, we can send you a Serial Cable as a temporary fix.
2) It may be that the USB Driver has not successfully installed. Please check in "Device Manager" to see if you have an "Other Device" showing. If so, please remove this "Other Device", uninstall the Driver, reboot your system and then reinstall the driver.
3) Check in the "Ports (Com & LPT) Folder and you should see a port reading something along the lines of "Prolific USB-to-Serial Comm Port (Com #)". The COM port being used will be in brackets.
Once you have established this, go back into the OneTouch software, click on PREFERENCES and under the General Tab, in the Look for Meter On section, uncheck the Autosearch box and choose the current COM PORT used. Click SAVE:
It was the third option that worked for me.
Now having lots of fun (!) which all the charts and graphs, it's actually picking up some things that I hadn't which is useful.