I think some of the reactions to tirpezatide, semaglutide, the others further back in the pipeline, are fascinating. Just from the weight loss perspective, it's as if some people think *really* dealing with weight issues involves struggle against moral or cognitive flaws and these drugs are cheats which let you pretend to have dealt with these flaws while allowing them to continue to fester.
If you lose weight and keep it off without subscribing to some quasi-religious little food purity dogma - low carb, low fat, now low UPF - and making yourself a *better human being* you're cheating and your flaws will continue to poison your soul and psyche despite your artificially-skinny outer form. Or something.
It's just such crap. The huge demand for these drugs is driven mainly by the very large number of people who have struggled with weight forever, spent huge amounts of mental and emotional energy on trying every behavioural strategy and dogma for dealing with it, and not succeeded because their peptides are out of whack.
I'm coming up on five years of ~25% sustained body weight loss, via calorie coutning, simple mindfulness, frequent weighing and a bunch of exercise, and I have absolutely nothing to teach most of these people about anything. They've tried it all, and more, and worked harder at it than I've ever had to. The difference is I'm one of the minority of people who got lucky with their peptides etc, and they are not. Now they have medication options (modulo availability, and obviously modulo individual responsiveness and side-effects) to make up for that, and it's a great thing.