New global health emergency declared

Bruce Stephens said:
I'm not sure it's known. While it's an old disease, mostly it affects people in poor countries and research is limited. Even in the best situations, I think determining transmission details is just tricky.
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There is the possibility, the newer clade 1b is vaccine resistant. In that instance, especially if there is higher mortality, in terms of strategies, e.g social distancing, working from home, closing venues may become the norm again.
 
@Amity Island Ok, I tripped over this link in a news story - I think you'll like it - https://www.ecdc.europa.eu/en/news-...ore-imported-cases-clade-i-mpox-highly-likely

Of note on that page is a link to a Factsheet for health professionals on mpox (monkeypox)
One or 2 bits from the health professionals page (care here as it talks of the 2022 and the 2024 outbreaks)
"viable MPXV can be detected on household surfaces at least 15 days after contamination of the surfaces"
(regarding general pox viruses) ... "poxviruses are sensitive to common disinfectants. However, they can be less sensitive to organic disinfectants"
"the incubation period for mpox is described as usually lasting from 6–13 days, but may also range from 5–21 days"
"Evidence is still emerging regarding transmission routes and transmission dynamics in the clade I outbreak in DRC and other African countries, but multiple modes are being reported, including sexual and household transmission"

Potentially useful list of references on the healthcare professional page - I've not looked at them yet
edit - ok this could be a useful reference (but at present is quarterly) - https://monkeypoxreport.ecdc.europa.eu/
 
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I think many lost a lot of trust in .gov uk health, but for what its worth here is the .gov info;
www.gov.uk

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Find content from government
www.gov.uk www.gov.uk
 
Amity Island said:
There is the possibility, the newer clade 1b is vaccine resistant. In that instance, especially if there is higher mortality, in terms of strategies, e.g social distancing, working from home, closing venues may become the norm again.
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Sure, could happen. This one appears to be infecting children quite a bit, so if we imagine it looks like it's going to spread widely and is likely to kill upwards of 1% of infected children, dramatic action seems unavoidable. I think that's rather unlikely but I don't suppose it's impossible.
 
s'nic said:
"Evidence is still emerging regarding transmission routes and transmission dynamics in the clade I outbreak in DRC and other African countries, but multiple modes are being reported, including sexual and household transmission"
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I read something that suggests the transmission routes for smallpox are also pretty uncertain. (Obviously it can't be studied now but it was around for a very long time so I'd have thought scientists would have a decent understanding of it, but apparently there's significant uncertainty.)
 
Bruce Stephens said:
I read something that suggests the transmission routes for smallpox are also pretty uncertain. (Obviously it can't be studied now but it was around for a very long time so I'd have thought scientists would have a decent understanding of it, but apparently there's significant uncertainty.)
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It's the clade 1b that is relevant at the moment. I'm not seeing any specific info on the new 1b at all, it's all getting mixed in and muddled up with the other variants.

Will the vaccines be specific for clade 1b, if not, they may not be of much help.

I'm interested in what claims they will be making or others will be making. Transmission, infection, relative and absolute risk reduction, illness, death, mandates etc.

The difference this time is, many will be fully informed in terms of the questions that need to be asked and what the answers mean. People may have the chance to get informed consent this time. Will people be as quick to take Vax if they are informed the absolute risk reduction is less than 1% like the COVID vaccines were? And, that they don't prevent infection, illness or transmission.
 
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Bruce Stephens said:
Sure, could happen. This one appears to be infecting children quite a bit, so if we imagine it looks like it's going to spread widely and is likely to kill upwards of 1% of infected children, dramatic action seems unavoidable. I think that's rather unlikely but I don't suppose it's impossible.
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With COVID at least;

Broadly speaking, for each vaccinated child that was spared a visit to the hospital due to Covid another sought treatment for heart damage.

To prevent one additional visit to A&E for COVID we had to spend £1,280,000 on vaccines.

Post in thread 'Covid-19 response' http://forum.diabetes.org.uk/boards/threads/covid-19-response.105518/post-1368738
 
From what I've seen so far current vaccines seem based off the smallpox vaccine, this section is from https://www.who.int/emergencies/disease-outbreak-news/item/2023-DON493 dated Nov 2023

Vaccines and antiviral treatments
Vaccines for the prevention of mpox are composed of vaccinia virus and were first developed as safer vaccines for the purpose of smallpox preparedness: third-generation vaccines causing fewer side effects than the vaccines used during smallpox eradication are available. These include MVA-BN, first approved for the prevention of mpox in 2019 and the LC16-KMB vaccine approved for mpox in 2022. These vaccines offer 66-90% protection against mpox due to the antigenic similarity of the viruses that cause smallpox and mpox. A few countries maintain stocks of vaccines against smallpox and mpox, especially since the start of the global outbreak in 2022. Vaccination against mpox is recommended for persons at risk of contracting the disease, including children, and persons who have been in close contact with someone who has mpox.
Antivirals are also being developed and a clinical trial of the antiviral agent tecovirimat is ongoing in the the Democratic Republic of the Congo in two district hospitals in the provinces of Maniema & Sankuru. In order to access tecovirimat in the country, a request can be made to national health authorities.
 
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