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Intensive insulin treatment

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JoeJOns

Active Member
Relationship to Diabetes
Type 1
Hi guys,

What is the definition of "Intensive Insulin treatment"? From what I have read online it is a basal bolus insulin regime? Which I am actually on at the moment.

Are the benefits significant? I am finding I am having quite a few hypos at the moment. Which to my knowledge comes with this sort of treatment.

Thanks guys.
 
It used to be that you were on fixed doses of insulin and fixed amounts of carbs which was less flexible in terms of eating but also less responsive to the general ups and downs of diabetes. MDI (multiple daily injections) or pump therapy both offer tighter control of your diabetes and better health outcomes in the long run. If you’re fairly newly diagnosed there will be a lot of tweaking and adjustments to your doses but you will soon get the hang of what foods spike your glucose quickly and what have a later spike and maybe adjust when you take your insulin or how much insulin you take accordingly. Lots of hypos can be a sign you’ve not got the ratios of insulin to carbs quite right or that your insulin sensitivity at certain times of day is different. Your diabetes nurse will work with you to learn how to adjust that. Are you keeping records of your glucose and insulin? It can help to keep a diary (your DSN may have given you one) or a spreadsheet as you can spot patterns that way that may show which ratio needs adjusting or that you may need to do an exercise adjustment or whatever.

It’s all a big learning curve and even when you’ve been living with diabetes for a long time it will throw curveballs. Try not to worry too much if the hypos are moderate especially if you’re hypo aware but so keep your nurse in the loop as they can advise and adjust things (and there will be lots of adjustments to begin with).
 
Thank you for the reply!

Can I ask, what are some of the most common ratio's? At the moment I am on a 1-10 ratio.
 
Hi. I am on a Basal bolus regime I think most people with T1 are . I find it very flexible

If you are having quite a few hypo’s it means that either your basal, bolus or both ratios are not right yet , it would be best to keep in close contact with with your DSN. Also our ratios can change quite a bit through the year.

When are your hypo’s happening.
 
1:10 is common, but it does vary quite a bit from person to person (and also from meal to meal and season to season - I tend to need around 1:10 for breakfast most of the year, but I can need as little as 1:28 for lunch, depending on the weather!).

If you're having a lot of hypos it probably means the doses they guessed when they diagnosed you are not quite right, so you need to talk to your diabetes specialist nurse about adjusting them.
 
Are the benefits significant? I am finding I am having quite a few hypos at the moment. Which to my knowledge comes with this sort of treatment.

The benefits of a basal/bolus scheme are that you can be flexible about eating while still keeping reasonable control of BG. With mixed insulins (or similar) you need to fit your meals to the insulin (so you need to eat at more or less fixed times and so on). Better control reduces the risks of some complications, and the flexibility means you can (reasonably) safely skip lunch if that's convenient without risking a hypo. It's the usual regime now, though because it's a bit complex it's not going to be suitable for everyone.

You'll be expected to modify the ratios yourself to get them right (to minimise hypos, for example). But before you get there, as others say, contact your healthcare team and see what they suggest. (Maybe they'll suggest lowering basal levels a little.)

They'll want to try and reduce your hypos. Hypos are bad in themselves (they're risky, for one thing) and they tend to be followed by going high.

You're right that lowering BG on average is going to increase the risk that sometimes you go too low. It was probably worse back when the large studies were done since more modern insulins have better profiles, but it must still be the case. (And, for those who have continuous monitoring, that makes it much easier.)
 
Hi. NICE recommends that all T1s are on Basal/Bolus. This regime is only likely to result in frequent hypos if you don't carb count, don't balance the Basal and don't use a ratio that works for you. I've only had a hypo that woke me up once in 2 years; perhaps I've just been lucky. Note that it is really essential to carb-count despite GPs/DNs often leaving this for a training course many months after starting insulin. I've never heard of 'intensive treatment' and to me has no meaning. My ratio tends to be nearer to 1:8/1.9 than 1:10.
 
Thank you for the reply!

Can I ask, what are some of the most common ratio's? At the moment I am on a 1-10 ratio.

As other have suggested, while it can be helpful to know what other ratio works for other people, the more important thing is to work out what basal dose and ratio work for you *at the moment* and then use it until it doesn’t seem to work reliably any more (or at that time of day) and then change it in smallish increments, perhaps 10%, up or down until it works.

My definition of ‘works’ is something like:

Basal should hold your levels steady if you miss a meal and overnight. You can skip a meal or set an alarm or two to check this. ‘Steady’ means not rising or falling by more than 1.5-2mmol/L. Your BG is likely to dip in the early hours. The more steady your basal holds you when not eating or exercising, the more effective your meal doses will be.

Bolus: Doses matched with accurately carb counted meals or snacks should return BG to the starting point after 4-5 hours. Meals/snacks should be chosen, and doses should be timed to give a rise of max 3mmol/L and ideally so that BG peaks ideally no higher than 9mmol/L (for timing... sometimes you need to leave a gap between dose and eating). Peak BG can be given some flexibility depending on premeal BG.

Range: best discussed with your clinic, but research seems to suggest that aiming to be within 4-10mmol/L at least 70% of the time is ideal.

Hypos: As feels as possible. You should aim to be able to go several days (most days?) with no readings below 4.

This is intensive management. 🙂

Non-intensive management would be mixed insulin twice a day, and not counting carbohydrate but just being told to eat a ‘healthy’ diet.
 
It is unusual for people with T1 not to be put on basal/Bolus regime (described as intensive therapy).

As others have said you will gradually work out what ratios you need for you. 1:10 is a common starting point and then working up of down from there as necessary. At this early stage try not to worry about that, however it would be good to talk to your DSN about possibly changing basal (background) doses or Bolus ratios in order to reduce the number of hypos.
 
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