How the insulin receptor works

[Northerner]

As we are approaching the 100th anniversary of the discovery of insulin, a wide array of its signaling pathways has been defined. However, the initial step in insulin action, i.e. the engagement with its cell-surface receptor and the resulting conformational change, which propagates across the plasma membrane to the intracellular module, remains poorly understood. Addressing this problem, researchers from the Paul Langerhans Institute Dresden of the Helmholtz Zentrum München at the University Hospital Carl Gustav Carus of TU Dresden together with colleagues from Rockefeller University New York succeeded for the first time in the visualization of the insulin receptor activation. The results of this collaborative work have now been published in the Journal of Cell Biology.

https://www.sciencedaily.com/releases/2018/02/180219103256.htm

 

[trophywench]

Gosh! LOL - it remains to be seen however whether it helps anyone now we all know this - so I think I'll wait till they announce what practical use it might have for anyone!

 

[mikeyB]

It may help to explain insulin resistance, it’s not just an academic achievement.

 

[trophywench]

Please can all the Type 2s with insulin resistance on the forum who have not had medical training in the past, confirm that they know understand their insulin resistance or feel they are on the way to understanding it ?

Maybe I just don't see the need to know this, because I haven't got IR?

 

[trophywench]

Hiya Trnt - what on earth do you mean about cancer-causing, and what products of synthetic insulin are you referring to (I didn't know there were any)

 

[grovesy]

Hiya Trnt - what on earth do you mean about cancer-causing, and what products of synthetic insulin are you referring to (I didn't know there were any)

I think they are reffering to some of the Type 2 injectable drugs.

 

[trophywench]

I didn't realise any of them were carcinogenic though.

 

[Robin]

I didn't realise any of them were carcinogenic though.

I think pioglitazone was withdrawn after a link with bladder cancer was found.

 

[trophywench]

Well of course Robin any new drug for anything might have side effects after longer term use, that can't be detected in the shorter term but if we had to wait that long for anything new discoveries would never get licensed in the first place, cos who the heck could possibly afford to do all the research and pay for the various clinical trials with all the admin involved in that as well - without being able to foresee any possible return on their investment for a decade or more?

There would be no medical research !