Fiasp - Faster Insulin Aspart - some first impressions

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I started using Fiasp a few weeks ago, I carry a pen and tester at all times and it appears to stop working when warm, has anyone else had problems with this insulin not working?
 
Pumper_Sue said:
I have just read this report by Tim http://www.diabettech.com/faster-insulin/new-kid-on-the-block/ do read it carefully before you jump ship.
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I've just been prescribed FIASP, don't think I will change to it after reading that, at least for now. Stick with Humalog, it's a bit too long lasting for me humalog, but at least it works well and is predictable. My consultant offered the fiasp probably without knowing that much about its constituents, manufacture or effects.
 
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tim2000s said:
Hi Everyone, I managed to get my hands on Fiasp on Friday and have been trying it out over the last few days. I'm reasonably impressed with what I've seen so far.

On Friday, I gave it a 10 minute pre-bolus trial on a Krispy Kreme donut, and the result was below. For comparison sake, with NovoRapid, I need a 30-40 minute pre-bolus to see similar effects.
QqLNADG.jpg


I've also undertaken a few "Time to action" tests to see what my ISF looks like with it. So far, on repeat testing, I've seen the below effect, which suggests that 1u is starting to act in accordance with the guidance from Novo, and that due to the early higher absorption rate, although the tail is the same length, the amount of insulin available for the tail is lower so it doesn't have as much of an effect:

sBO0z5g.jpg

There are more details here but so far I'm suitably impressed with the performance I've seen. It does take effect more quickly and the post-prandial rises have been lower than they would have been with NovoRapid at the same timing.

It's not Afrezza, in that it doesn't have an instant hit, but it is noticeably better than NovoRapid for when you are late bolusing.
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Hi, I was recently prescribed FIASP by a diabetes consultant, but after reading the review below linked here from pumper sue "I have just read this report by Tim http://www.diabettech.com/faster-insulin/new-kid-on-the-block/ do read it carefully before you jump ship" - I think i'll stick with the humalog for now, it's predictable for me, I'll wait for some more reviews on the fiasp. Please keep us all up to date with how you get on with FIASP your graphs and info are really good.
Thanks
 
I've been using it for a few months. Takes some getting used to, and the activity is noticeably different (faster) to NovoRapid in various circumstances. Quite similar in others though. You just have to relearn the 'exceptions to the rules' that you instinctively apply to your current insulin.

Certainly haven't noticed any problems in the heat, but I did seem to get a change in sensitivity (I needed more insulin for the same effects) after afew weeks. Has settled since though, and I've seen lower spikes and faster rising BG resolution than I would have expected from NR.

As I say, it's not a straight like-for-like switch though, and you do need to learn how to use it to suit your body.
 
I have FIASP in my pump this afternoon due to beef insulin being discontinued in the near future and so far so good I've held steady between 6 and 4.6 since 3pm, which is a great improvement from previous insulin's.
Obviously only 4 hours in so no idea what the night will bring or the following days. I'm running it at 20% less basal to play it safe as no idea if I will have any hypo warnings and have set the pump to shut down after 6 hours if no button pushes so at least I stay safe.
 
Having read the great report on Fiasp, I have returned to my reliable Humalog as I was getting highs of 20 and my normal batting average is, 6.5 - 7, I think that having been a type 1 for some 40 years, since the age of 13, the effects were dreadful although the first fortnight they were good!
Its incredible its taken this old dinosaur till the ripe age of 53 to ever think of using a forum like this, seems there is life in the old dog yet! and thank you all for your very valuable help.
 
Phil65 said:
Agreed TW, the conundrum of Diabetes.
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To quote my endo, "It makes no sense". (How many years did she study to come to that conclusion?:confused:)
 
Pumper_Sue said:
I have FIASP in my pump this afternoon due to beef insulin being discontinued in the near future and so far so good I've held steady between 6 and 4.6 since 3pm, which is a great improvement from previous insulin's.
Obviously only 4 hours in so no idea what the night will bring or the following days. I'm running it at 20% less basal to play it safe as no idea if I will have any hypo warnings and have set the pump to shut down after 6 hours if no button pushes so at least I stay safe.
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Be really interested to see if you seem to need an (upward) reset of basal profile and/or meal ratios after a couple of weeks Sue. Tricky thing for me is that I can't tell if it was just my diabetes just doing it's normal nonsensical goalpost-shifting, or whether it was connected to the new insulin. It's easy to attribute a change to something you know you are doing differently, whereas if I'd not changed anything I would have just rolled my eyes and known it was my diabetes playing silly games.
 
everydayupsanddowns said:
Be really interested to see if you seem to need an (upward) reset of basal profile and/or meal ratios after a couple of weeks Sue. Tricky thing for me is that I can't tell if it was just my diabetes just doing it's normal nonsensical goalpost-shifting, or whether it was connected to the new insulin. It's easy to attribute a change to something you know you are doing differently, whereas if I'd not changed anything I would have just rolled my eyes and known it was my diabetes playing silly games.
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My basal does tend to change when I have an MS flare so nothing in that dept would surprise me 🙂 after almost 24 hours on it and fairly steady bloods and no shift in the actual basal pattern which did surprise me I'm more than happy. I do have a muggy headache and feel sick so hoping that wears off soon. All I need is a hypo so I know I can detect them 🙂
 
Pumper_Sue said:
My basal does tend to change when I have an MS flare so nothing in that dept would surprise me 🙂 after almost 24 hours on it and fairly steady bloods and no shift in the actual basal pattern which did surprise me I'm more than happy. I do have a muggy headache and feel sick so hoping that wears off soon. All I need is a hypo so I know I can detect them 🙂
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I start mine tomorrow. How are you finding it. I'm starting it on my omnipod pump only my 3rd week on a pump to. Anything i shoukd be aware of please?
 
Wassy said:
I start mine tomorrow. How are you finding it. I'm starting it on my omnipod pump only my 3rd week on a pump to. Anything i shoukd be aware of please?
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Hi Wassy and welcome, I've left my comments in the pump forum 🙂
 
I have said & noticed my Novorapid does not work fast enough for me. Sounds good to me 😎
 
Just had this prescribed to replace NOvorapid. It has been very useful to read the reviews and articles. It looks like it could reduce the spikes but may well increase my sensitivity. I am currently on reasonably low ratios so that may not be a problem. It is good to be forewarned and I shall have to keep a watch on levels.
 
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