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Change of insuiln

I agree with @rebrascora - although the profiles are said to be different, I have also found that Levemir works for me almost identically to the "intermediate" insulin graph when you compare the two

View attachment 35848

Which is why (for me) I am looking for a change to something similar - did lots of exercise yesterday evening so skipped my evening dose altogether (something you can't do with longer lasting (once daily) basal insulins)
Ah, but those diagrams are out of context and thus misleading. The basal diagram, lasting 42 hrs, is unique to Tresiba. That basal profile may not suit everyone, but for those who want that sort of profile it is excellent - in that the actual delivery for me is extremely close to the theoretical profile. Only available from Tresiba, as far as I know.
 
It is a generic diagram yes - but the point I was making is that not all insulins have the same profile for different people (despite their "label" as Basal, Intermediate, etc.) - for me Levemir acts more like an Intermediate insulin in it's profile/length of working etc. Apologies for any confusion (should have explained myself better!)
 
@mashedupmatt, I fully recognise that our needs can be quite different. But sometimes we get entrenched into certain patterns and thus can lose sight of opportunities from using the available tools in different ways. I am potentially drifting off topic; the OP was asking about his changed mixed insulin as a T2 not on MDI. But Tresiba could be ideal for some T2s, with its particular longlasting profile.

I have in the past tried to make an explanatory business case for the benefits of Tresiba - partly based on the fact it works extremely well for me and partly because it is widely used and (seemingly well appreciated) in America. That latter justification could be prejudiced by the way health care is funded from insurance, rather than our NHS peculiar arrangements. I possibly explained myself on some date before you joined the Forum.

There is a sound counter argument that for ladies below a certain age the inflexibility of the 42 hr profile doesn't fit at all well with menstrual cycles. I have no idea how ladies across the pond manage this and I'm not going to get dragged down that rabbit hole. But from my perspective taking Tresiba needs a very different mindset than, say, intermediate basals. Because it has this extended flat profile it allows the user to gain a security and confidence that, once set up, it does its job very predictably. Today's dose is topping up yesterday and so a secondary benefit is that the user doesn't need to be too concerned about basal dose timings. I take mine when I wake and that can be between 6am or before midday, but typically 8am. I routinely have to increase my Tresiba dose in winter and reduce it for late spring into summer; otherwise I don't need to think about basal doses, so one stress point is significantly reduced. When I've had an extended period of ill health I have cautiously increased my Tresiba and invariably seen cause and effect response.

The reason I can make this work is because my mindset is that my basal has been optimised to keep me level and predictable through all sleeping hours and once awake I must use my bolus to manage my awake time. My basal is pretty fixed and not to be used for exercise/activity regulation, nor hyper corrections, nor for short term stress or any other external changes. The optimisation is very achievable thanks to CGM - my 24 hr graphs tell me that I'm getting those predictable sleeping and fasting protection periods; if not totally flat, certainly keeping me in range. If the daily graphs show a consistent drift over several days, then a modest basal change is appropriate. But such changes are rare. I know when that optimisation is compromised by a midnight feast or snack (and can see that cause and effect on the graph) or when my night was disrupted by the odd event (be that a late party or very early morning start). Such disruptive events are known and explainable.

But thereafter whatever my basal is bringing to my daytime party "is what it is", I don't need to allow for it or even consider it. I just need to let my bolus regulate my meals, variety of day to day activity and exercise - as each day unfolds. This mindset could be applied to a T2 who needs limited insulin support: the Tresiba does its best for helping manage the liver's glucose releases and the T2 user takes advantage of that, in conjunction with their discretion on meal choices and exercise/activity patterns. Since many T2s using insulin only once daily don't qualify for CGM, they don't get the opportunity to easily optimise their basal - but nor do they get that visibility for whatever insulin they are taking. They do get access to fp testing.

Anyway, this is probably a bit too much off piste - again. I'll stop.
 
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