'biggest ever' study on how to prevent children getting type 1 diabetes

[MrClean]

Wow. I was always under the impression type 1 diabetes was rare. 1:250 is not rare at all. So what is the incidence of type 2?

We know that approximately 90% of diagnoses are of type 2 diabetes, and around 8% of diagnoses are type 1 diabetes, with the other forms of the condition making up the remaining 2%. Date research was done 13 Apr 2023 Type 1 is the Rare of the conditions.

 

[everydayupsanddowns]

with the other forms of the condition making up the remaining 2%

Wouldn’t those data suggests that the types making up the 2% are the rare varieties? With T1 being relatively common, though still much rarer than T2 😛🙂

 

[Bubbleblower]

Basically we don't know what causes Type 1 or Type 2 but there is almost certainly a genetic disposition which can be triggered by various stimuli

That's what this interesting video is about:

Stress and neoantigens in type 1 diabetes

According to the video inhibitors of ER stress prevent the T-cell mediated destruction of beta cells.

 

[Amity Island]

That's what this interesting video is about:

Stress and neoantigens in type 1 diabetes

According to the video inhibitors of ER stress prevent the T-cell mediated destruction of beta cells.

Thanks, I'll have a watch later.

I'm as certain as I can be that stress was the primary trigger of my type 1.

I think humans are actually quite a fragile, sensitive creature. I've come to the conclusion it doesn't take a lot to disturb the balance in the mind and body. Hence, why there are so many issues with mental health. I don't think we give enough attention to the subtle changes in our bodies from day to day modern life. It's part of our human journey to move away from trying to conquer the world, fight against everything and everyone towards something more peaceful, calm and joyous. Some, spend their whole lives never realising this.

 

[Inka]

I don’t think it means mental stress @Amity Island I read it as a physical stress affecting the cells. There’s a description of the accumulation of proteins (?) that stress the cell.

I agree with your general points about mental/emotional stress though and doubt that kind of stress helps health.

 

[Amity Island]

I don’t think it means mental stress @Amity Island I read it as a physical stress affecting the cells. There’s a description of the accumulation of proteins (?) that stress the cell.

I agree with your general points about mental/emotional stress though and doubt that kind of stress helps health.

Hi Inka, thanks for pointing that out. I litterally mean mental stress creates a very real physiological response, that this physiological response can put immense stress on the body. That's what I believe triggered my type 1.

 

[MrClean]

Wouldn’t those data suggests that the types making up the 2% are the rare varieties? With T1 being relatively common, though still much rarer than T2 😛🙂

Type 1 classed as common, Fewer than one in 10 people in the UK who have diabetes have type 1 diabetes.Not exactly common is it. 5-10% of people with diabetes have type 1. Im not mention anything else about this now i get e general kind of feeling about things now have a nice weekend Buddy.

 

[MrClean]

So far, more than 10,000 newborns have been tested - with 50 signed up to the follow-up SINT1A study being led by the paediatric research team at the Royal Victoria Infirmary. SINT1A is the study to see if being given a probiotic can prevent diabetes developing.

'Biggest ever' study at Newcastle to prevent children getting type 1 diabetes

A study is examining whether we can prevent children from developing type 1 diabetes

www.chroniclelive.co.uk

Pary for those New borns i really hope this works. Good work they are doing.

 

[MrClean]

The last figures I read were something like 1 in 16 people in the UK have type 2 diabetes, and the figure is increasing.

Since I was diagnosed, I am quite surprised at how many people I know have it. When people ask me why I lost so much weight, and I say it was to try to improve blood sugar, they say, 'oh I've got that as well.' as if it's like having a cold. (Most are overweight, but I do know a few who have no weight issues and still have it.)

I know someone who is on the brink (hba1c of 47) and is making no attempt to change their lifestyle.

How come you was not diagnosed as a type 1 cause you lost lot's weight ?

 

[MrClean]

I read one paper years ago that said to be dxed Type 1 you had to have been given two bad copies of a particular gene that regulates glucose use, one bad copy from each parent. The parents themselves didn't need to be Type 1, they could have a bad copy of the gene and good copy of it.
But then again a Professor at Exeter, I think, also maintained that there is a bundle of genes that predispose to Diabetes and which type you get depends which combination of them you get and how it is triggered.
Basically we don't know what causes Type 1 or Type 2 but there is almost certainly a genetic disposition which can be triggered by various stimuli e.g. onset of Type 1 theorised as being triggered by first exposure to Cow's milk or dog bites ( yes the theorising is that desperate !) In the 1990s the theory was mooted that the genes for Type 2 are beneficial genes from the Paleolithic era - having raised bgs in middle age would help in a regime of feast or famine then. The advocates of that theory suggest the genes for Type 2 Diabetes must have been beneficial once because they have been so well conserved and passed on over millennia.

Thye do no what cause's Type 2 it's Type 1 that they don't no what cause's that.

 

[harbottle]

How come you was not diagnosed as a type 1 cause you lost lot's weight ?

I lost weight after diagnosed, not before. Low carb/calorie diet. Type 2 can cause weight loss as well.

 

[MrClean]

I lost weight after diagnosed, not before. Low carb/calorie diet. Type 2 can cause weight loss as well.

Are you taking Novorapid fast acting Insulin for day time and Trisiba or Lantus slow acting Insulin for night time, sorry hope you don't mind me asking and i hope you are doing ok with your diagnose's. Thank's for your reply.

 

[harbottle]

Are you taking Novorapid fast acting Insulin for day time and Trisiba or Lantus slow acting Insulin for night time, sorry hope you don't mind me asking and i hope you are doing ok with your diagnose's. Thank's for your reply.

I’m not taking insulin - just a low dose of Metformin.

 

[rebrascora]

My totally none scientific gut feeling is that we may have a genetic predisposition to autoimmune conditions and which one we get and when we get it may be down to environmental factors or just a combination of factors within the body. I had an uncle and I have cousins with Type 1 all on my mother's side. My mother developed rheumatoid arthritis (autoimmune) at menopause, I developed Type 1 at menopause and my sister developed PMR (autoimmune) at menopause. My thoughts are that the change of hormones plays a part and perhaps the change of hormones with children plays a part and maybe also the change of hormones in pregnant women, but obviously that doesn't explain all cases and there will no doubt be other trigger factors, like viruses and possibly even extreme shock but I see it as a bit of an autoimmune ticking time bomb with no certainly as to when it will go off or the impact it will have, like I got diabetes but my sister got PMR.
I am just looking at my own situation here and drawing some very sketchy lines of inference!

 

[MrClean]

I’m not taking insulin - just a low dose of Metformin.

Wish i could do that i gotta use Insulin and needles, i Type 1 so only can use Injections, so you get the Glucose suger) lows as well do you mine are always low hide to control still even tho i was diagnosed Type 1 in 2003, my Suger ows are like 2.1 3.2 4.2, scary when it happens, espically if im in a Public place.

 

[rebrascora]

Wish i could do that i gotta use Insulin and needles, i Type 1 so only can use Injections, so you get the Glucose suger) lows as well do you mine are always low hide to control still even tho i was diagnosed Type 1 in 2003, my Suger ows are like 2.1 3.2 4.2, scary when it happens, espically if im in a Public place.

Do you have Libre or other CGM? If so, what do you have your low level set at?

 

[MrClean]

Do you have Libre or other CGM? If so, what do you have your low level set at?

Libre i have 2 Sensors a Month and i have my OneTouch or backup, i have high Glucose off and Low Glucose off in the Libra settings, i have had the Libra for a while now i should realy use these settings, my Type 1 diabetes i have had since 2003 and i get that many Hypoglycemia episodes my body thinks that a low glucose is normal i rarely get the shakes anymore, so now i need to start keeping my glucose a bit highter so when i do have a Hypoglycemia episode my body can warn me as well as the Libra 2 Sensor.

 

[rebrascora]

@MrCleanThe main benefit of Libre and other CGM is getting advance warning or an impending hypo with the alarms and heading it off before it happens, particularly if you have dulled hypo awareness, so you would be well advised to turn on the low alarm and set it higher than 4, perhaps nearer 5, so that you can improve your hypo awareness. We have some people here who have good hypo awareness but still set their low alarm above 5 so that they can monitor things when levels are getting low and have a small carb snack maybe just 5g carbs like a single jelly baby or dried apricot if Libre indicates that their levels are dropping. I currently have mine set at 4.2 which is usually enough time to head off a hypo but thinking of setting it higher again as life has been hectic recently with more physical activity and I am not catching them soon enough as a result.

 

[Inka]

Libre i have 2 Sensors a Month and i have my OneTouch or backup, i have high Glucose off and Low Glucose off in the Libra settings, i have had the Libra for a while now i should realy use these settings, my Type 1 diabetes i have had since 2003 and i get that many Hypoglycemia episodes my body thinks that a low glucose is normal i rarely get the shakes anymore, so now i need to start keeping my glucose a bit highter so when i do have a Hypoglycemia episode my body can warn me as well as the Libra 2 Sensor.

Why do you have the alarms off, particularly the Low one? I’d set the Low alarm at 5.6 to try to get hypo alerts in good time. If you have hypo unawareness you might be entitled to a Dexcom CGM which has more warnings eg Falling Fast, Urgent Low, etc, and allows you to set the Low alarm higher to ward off as many hypos as possible and hopefully help restore some awareness.

 

[trophywench]

Getting back to the start of the thread, they reckoned my T1 was probably triggered to a virus I'd had in the February - a gastric virus. Aaah, gut microflora ......