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Aetiology of type 2 diabetes: an experimental medicine odyssey

JITR said:
Why not write to Roy Taylor at Newcastle University with a more detailed chronology? He would be able to tell you how your experience could fit the twin cycle hypothesis, or yours, as the case may be.
Click to expand...

@JimmyBlue

A couple more thoughts came to mind on my walk yesterday evening.

In terms of Prof Taylor's work, I wonder whether you have a 'low personal fat threshold' (you are slim) and would prove to be a 'non-responder' to a low calorie diet (your HbA1c came down only after ketosis).

The capacity of your pancreas to produce insulin could have been compromised while your diet was heavy with carbs in your 40s, 50s and early 60s. If you have a low personal fat threshold, excess glucose will not be stored as fat but may well find a way to damage the beta cells in your pancreas.

For an example search for Prof Tim Noakes descriptions of excessive carb loading when he was an athlete. He says his carb tolerance is now no more than 25g per day. Link to one of them: Full Timothy Noakes interview from Carb-Loaded documentary (timed to start at 'The rise of carb loading').
 
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