Aetiology of type 2 diabetes: an experimental medicine odyssey

[Eddy Edson]

Just-published Roy Taylor review of the "prolonged research endeavour to test the twin cycle hypothesis that type 2 diabetes is caused by fat-induced dysfunction of the liver and pancreas, guided by the happenstance of clinical practice."

A great resource!

Aetiology of type 2 diabetes: an experimental medicine odyssey - Diabetologia

This review describes a prolonged research endeavour to test the twin cycle hypothesis that type 2 diabetes is caused by fat-induced dysfunction of the liver and pancreas, guided by the happenstance of clinical practice. Testing of the personal fat threshold hypothesis, that individuals exhibit...

link.springer.com

 

[JITR]

Bravo!

Note from the paper: 'This review was invited based on the Claude Bernard Lecture at the EASD, September 2024'

Link: Claude Bernard Lecture at the EASD, September 2024'.

 

[beating_my_betes]

Thanks for this! Quite a lot to get though, here.

One of my biggest worries is that due to having higher levels for quite a while, I would've lost enough beta cell function to never be able to be fully cured. And while that is still a major concern, I am somewhat buoyed by this section:

 

[silver minion]

An interesting if very long read. It certainly gives hope for remission for a lot of type 2s.

Unfortunately I don't seem to fit the profile. I was overweight post covid and led a mostly sedentary lifestyle so I did diet and increased exercise, and BMI dropped from 29 to 26. Stopped dieting over Christmas and noticed in Feb that I was still losing weight although my calorie intake was back to around 2000 per day. Over the next 12 months with undiagnosed diabetes my BMI had dropped to 18 without dieting. I had little if any visceral fat by then and still have a slim waist/tummy now. Prior to diagnosis I had gradually increased my calorie intake to over 4000 per day and I felt permanently hungry and thirsty and was still losing weight.
Since diagnosis and medication plus a reduced carb diet of 2000 calorie per day I have slowly regained weight and muscle mass to a healthy BMI of 21 as my blood glucose has reduced. I am now struggling to continue reducing my BG and keep my weight at its current level.