Northerner
Admin (Retired)
- Relationship to Diabetes
- Type 1
Peglispro allows slow insulin absorption, but associated with injection site reaction and increased ALT and triglycerides…
Peglispro or pegylated lispro insulin is currently under phase III investigation for both type 1 and type 2 diabetes. The large hydrodynamic size of peglispro allows slow insulin absorption and reduces clearance, resulting in prolonged duration of action.
It also has reduced peripheral effects thus resulting in a hepato-preferential action more like endogenous insulin. Several studies have been conducted to evaluate the effects of peglispro in A1c reduction, nocturnal hypoglycemia, and changes in lipid panels.
http://www.diabetesincontrol.com/ar...illy-insulin-a-better-alternative-than-lantus
Peglispro or pegylated lispro insulin is currently under phase III investigation for both type 1 and type 2 diabetes. The large hydrodynamic size of peglispro allows slow insulin absorption and reduces clearance, resulting in prolonged duration of action.
It also has reduced peripheral effects thus resulting in a hepato-preferential action more like endogenous insulin. Several studies have been conducted to evaluate the effects of peglispro in A1c reduction, nocturnal hypoglycemia, and changes in lipid panels.
http://www.diabetesincontrol.com/ar...illy-insulin-a-better-alternative-than-lantus
