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Has anyone been prescribed Mounjaro? - new drug for weight loss approved by MHRA for people with type 2 diabetes.

M

Mimi66

New Member
Relationship to Diabetes
Type 2
Hello
I am struggling to get my levels down and am sensitive to many drugs! I have tried to persevere with taking Metforemin twice a day but the stomach pains and associated problems have meant I have reduced it to once daily. I am taking quite a high dose of Toujeo every morning by injection. I have also recently started on Dapaglifozin and in addition my diabetes nurse specialist wants me to try a new ‘wonder drug for weight loss’ Mounjaro which is given in a once weekly injection.
I have researched some of the available literature on the trials results and it does seem to have good benefits for weight loss. I am unsure about possible risk factors or side affects and would be grateful for any helpful feedback please?
Many thanks.
 
Hi, I started on 2.5 mg of Mounjaro 4 weeks ago going up to 5mg next Friday, no problems so far but I'm also on Sukkarto tablets, Toujeo 50 units AM and Novorapid twice a day.
How have you been on Mounjaro, I read there is already a supply problem if the higher doses in the US, I had to come off Trulicity for the same reason, I had been happily on it for 3 years until I couldn't get it anymore
 
I just started it 2 days ago. Side effects: the day after your injection you might feel nauseous. If you eat too much you'll definitely feel sick. I believe it can temporarily worsen diabetic retinopathy. My waking blood glucose level has halved in 3 days! I'm 0.2 away from non-diabetic range. I haven't seen those results since I lost 27lb on low carb in the first lockdown (why yes, I did put it all back on again.)
 
Mimi66 said:
Hello
I am struggling to get my levels down and am sensitive to many drugs! I have tried to persevere with taking Metforemin twice a day but the stomach pains and associated problems have meant I have reduced it to once daily. I am taking quite a high dose of Toujeo every morning by injection. I have also recently started on Dapaglifozin and in addition my diabetes nurse specialist wants me to try a new ‘wonder drug for weight loss’ Mounjaro which is given in a once weekly injection.
I have researched some of the available literature on the trials results and it does seem to have good benefits for weight loss. I am unsure about possible risk factors or side affects and would be grateful for any helpful feedback please?
Many thanks.
Click to expand...
Yes I started it a while ago I’m on my third lot of 5mg injections. So far I’m only losing a very small amount of weight so far. I’m on quite high doses of Toujeo and Trarapi insulin. I’ve started swimming again hoping to swim six times a week and when wheelchair basketball starts again once a week.

I’m hoping that now I’m exercising more my weight loss will be better. I’m due for my annual bloods in August. I have just over five weeks before I have them done. In my area they only go up to 5mg injections I wish they did the other strengths as I think it would be better weight loss.
 
I’ve been prescribed mounjaro, now on 5mg, having terrible tummy cramps and diarreahea now for several days, not sure if I can continue using this. I take metformin and have been taking humilin i and humalog before my nurse changed me to mounjaro.The side effects seem to go off slightly before my next injection a week later but I’m not having any sleep as stomach feels like a gurgling volcano. I am losing weight but I too have been going to slimming world and weight been slowing coming off without having to use mounjaro. I only take a small dose of humilin I & humalog so I may go back to the way things were, I have enough to worry about with my neuropathy in my legs let alone stomach cramps, nausea and diarreahea. How is everyone else doing?
 
I’ve been on Mounjaro for just over a month now
so far it’s OK for me, (as we’re both Ozempic & Trulicity)
My GP has just increased the dose from the initial 0.25 to 0.5

a few years ago I was taking Ozempic
without real side effects lost 6 stone (which I needed to)
mostly with the aid of Ozempic & obviously a lower carb diet
and was eating child sized portions

they moved me from Ozempic to Trulicity
as I’ve been under the DMO clinic (Retinopathy problems) for nearly 8 years now
the Retinopathy although wasn’t bought on by the Ozempic,
the Eye Dr suggested substituting Oxempic as a rare side effect of Ozempic can be Retinopathy problems

To many years in the past for to long I let my Diabetes be totally out of control

Ozempic I felt was ok for me and no real aside effects (apart from doing its job and surpassing my appetite)
after I was moved from Ozempic to Trulicity earlier this year
suddenly it wasn’t available due to supply shortages.

then a few months ago the DSN suggested I might want to try Mounjaro as it was now available,
however before my GP was happy to prescribe, I had to get a letter from Eye Department confirming they would be happy for me to be on Mounjaro from DMO clinic.
 
With regards to injections like Ozempic and Wegovy etc, did anyone see the documentary on TV a few months back where they looked into why there was such a shortage of all these weight loss drugs ? I watched it myself and was appalled that the private Doctors are buying it for their clients.

When I listened to the program, in particular Ozempic, which helps with controlling our diabetes, why are these private Doctors prescribing something that most of those that might want to lose a few pounds, don't need, Wegovy is the one they need or any similar product that has no effect on diabetes. This is why there is a shortage of these medications.

Again, I was on Instagram a while ago and I kept seeing all these adverts for all these weight loss injections, all with various names, including Ozempic, the lowest price was £97 for one injection, the most expensive was £249. There is no regulation for this, it's so wrong. I could not get the 0.5 Ozempic after using the 0.25, so was put on Semaglutide tablets, they don't work as well as the injections, but they are the easier option.

I am coming up to my 2 year anniversary of being diagnosed type 2, have had 2 eye tests for Retinopathy and thankfully have passed both, so don't have to go back for another test for that for 2 years now. I do need to get some new glasses though, as my sight has been slightly affected for having T2.
 
been on it for 2 months just started my 3rd pen today 5mg as i was feeling sickly they did not increase the dose to see if another month at 5mg would help the nausea settle. the only issue i have found is my nurse did not mention to me not to drink alcohol while on Mounjaro and i have a few glasses for wine at the weekend and felt really strange took my blood reading and it was low. after some internet searching found that it was a common side affect if you mix the injection with alcohol so be careful if you are planning a celebration.
 
Hxx said:
i have had my first blood tests back today since starting mounjaro and my Hba1c has gone from 58 to 42, really pleased.
Click to expand...
Congratulations on your HBA1C coming down to 42. My last reading was 58. I have recently taken my second dose of 0.25 Mounjaro, I have had no side effects from taking it yet ! I was fine when taking Ozempic, but could not get hold of the next dose, so could no longer take it. One thing I did find with Ozempic, and I am not sure if this is only something I noticed, but it started to regulate my passing of urine better, I was not having pass water as often as I do normally, have/has/did anyone else notice anything like that while taking Ozempic ?
 
brettr said:
Congratulations on your HBA1C coming down to 42. My last reading was 58. I have recently taken my second dose of 0.25 Mounjaro, I have had no side effects from taking it yet ! I was fine when taking Ozempic, but could not get hold of the next dose, so could no longer take it. One thing I did find with Ozempic, and I am not sure if this is only something I noticed, but it started to regulate my passing of urine better, I was not having pass water as often as I do normally, have/has/did anyone else notice anything like that while taking Ozempic ?
Click to expand...
Yes I agree about not having to pass urine so much especially at night, now worried that I'm not drinking enough! I used to get up at least 4 times in the night now it's just once!
 
Hello, after my second prescription for Metformin, the first time many years ago for gestational diabetes, I find that I cannot tolerate the stomach cramps, headaches, nausea and eventually sickness. I am considering self funding a three month private prescription for Mounjaro as my GP practice won’t consider funding it on principle.
In recent years I have managed my T2D through low carb diet but in th last year, this has proved less affective and my last HBa1c has moved from the prediabetic range to 59. My best result.was 39 three months after I was first diagnosed achieved through changes in diet,

Given my sensitivity to Metformin, I am concerned that I might also have a bad reaction to Mounjaro. I feel I need to take some action, other than diet, and wondered if anyone had any updates or experience of both medications to share?
 
Ruby/London said:
Hello, after my second prescription for Metformin, the first time many years ago for gestational diabetes, I find that I cannot tolerate the stomach cramps, headaches, nausea and eventually sickness. I am considering self funding a three month private prescription for Mounjaro as my GP practice won’t consider funding it on principle.
In recent years I have managed my T2D through low carb diet but in th last year, this has proved less affective and my last HBa1c has moved from the prediabetic range to 59. My best result.was 39 three months after I was first diagnosed achieved through changes in diet,

Given my sensitivity to Metformin, I am concerned that I might also have a bad reaction to Mounjaro. I feel I need to take some action, other than diet, and wondered if anyone had any updates or experience of both medications to share?
Click to expand...
I wonder if there is something more you can do with diet, what sort of meals are you having.
 
I am following the same, low carb diet that I started when first diagnosed. No change there, Basically, no beige food - bread, rice, flour, etc or fruit 80%of time.. No alcohol to speak of. Old methods don’t seem to work. I have had problems since bad reaction to 3rd vaccine booster, followed by Bells Palsy treated by steroids. 3rd covid infection resulted in long covid and respiratory problems. Respiratory problems are improving but blood glucose still haywire. Thought Metformin might stabilise things , as well as off label support for long covid but I can’t tolerate it. It is very hard to stay motivated when my efforts are no longer achieving desired outcome. My approach has been diet first and meds only as a last resort but I feel I am being forced to explore self funding options to bring about some change. I tired discussing this with my diabetic nurse but she kept telling me how stressed she was told me to discuss it with the pharmacist who informed me that the practice wouldn’t prescribe Mounjaro on principle.

If anything, the one thing that has changed is my energy levels which means I don’t exercise as much as I did.
 
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Ruby/London said:
I am following the same, low carb diet that I started when first diagnosed. No change there, Basically, no beige food - bread, rice, flour, etc or fruit 80%of time.. No alcohol to speak of. Old methods don’t seem to work. I have had problems since bad reaction to 3rd vaccine booster, followed by Bells Palsy treated by steroids. 3rd covid infection resulted in long covid and respiratory problems. Respiratory problems are improving but blood glucose still haywire. Thought Metformin might stabilise things , as well as off label support for long covid but I can’t tolerate it. It is very hard to stay motivated when my efforts are no longer achieving desired outcome. My approach has been diet first and meds only as a last resort but I feel I am being forced to explore self funding options to bring about some change. I tired discussing this with my diabetic nurse but she kept telling me how stressed she was told me to discuss it with the pharmacist who informed me that the practice wouldn’t prescribe Mounjaro on principle.

If anything, the one thing that has changed is my energy levels which means I don’t exercise as much as I did.
Click to expand...
Steroids are well known or causing elevated or hard to manage blood glucose levels.
It may help to go back to basics and keep a food diary for a week or so and note what you have and an estimate of the carbs to see if you have drifted upwards and your body is less tolerant of the carbs you are now having especially if your exercise has dropped down a bit.
Maybe doing some strategic testing of your meals to see if you are eating meals which increase your blood glucose by more than 2-3mmol/l from before eating to 2 hours after.
 
Thank you. I can factor in a carb audit. I was doing well on 100g a day but maybe need to revisit that. I would still be interested in hearing about people’s experience of Mounjaro. I am willing it trial it until my next Hba1c. I maintained testing for quite some time but gave up in recent months - mainly because my results were so out of whack. I even changed monitors because I thought it was broken. These days, my fasting blood and pre food reading is consistently 7 and over. Definitely, time for a reset.
 
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Just to check - did you try slow release metformin as well as standard? Some people can tolerate slow release that really didn't with standard.

If you did then it may be worth making an appointment to see GP/practice nurse and discuss medication again

This is the specific NICE guidance on Mounjaro and to be honest, if metformin is the only medication that you have tried, it doesn't currently support your request to try Mounjaro next https://www.nice.org.uk/guidance/TA924/chapter/1-Recommendations

However there are other medication options that they should be discussing with you and offering you if metformin isn't tolerated, this is the table of which medications should be offered in which order, depending on other diagnoses etc, followed by a table that gives more details about the medications. It states that the "flozins" can be used as first line therapy where people don't tolerate metformin and aren't able to maintain HbA1c with diet and exercise alone, and the medication list says that flozins are associated with weight loss so they may be more willing to consider that than Mounjaro as an initial medication. (Or you may feel that one of the medications labelled as no effect on weight might be one you are willing to try.) https://www.nice.org.uk/guidance/ng28/resources/visual-summary-full-version-choosing-medicines-for-firstline-and-further-treatment-pdf-10956472093
 
I am two weeks in and so far so good, blood sugar has dropped and my appetite has slightly receded, I have pre-orded my second months supply well ahead of time as I have heard that there are shortages (all the celebs overdosing on it I expect)
 
Ok, I have taken the plunge and taken my first 2.5 dose of Mounjaro today. I am self funding this for three months and will see what the results are after my next A1c. ...Hoping for proof of principle to take to GP practice at my next review. I am hoping this will be short term and a reset. I can't afford to self fund it long term. I must admit I am nervous but I need to take some alternative action.

@42istheanswer, I was prescribed slow release metformin but still had terrible side effects.
@Chris1573, I am encouraged by your post.

Given that Mounjaro is a prescription medication, I am surprised by the amount of stigma that has grown up around it.
I have cleared it with my GP for safety reasons but interestingly, I have not told any family or friends.

The coming weeks will tell...
 
Thank you for the information! I did try slow-release metformin, but unfortunately, I didn’t tolerate it well. I appreciate the guidance on the NICE recommendations regarding MounJaro. Given that metformin has been my only medication so far, I understand the need to explore other options first.

I’m definitely considering scheduling an appointment with my GP or practice nurse to discuss my medication alternatives, especially the “flozins” that may be more suitable for me.

Also, I wanted to mention that I had surgery at Florida Weight Loss MD, which has helped me significantly in my weight loss journey. I’m curious about the MounJaro injection cost and how it might fit into my treatment plan, but I want to ensure I explore all my options first.

Thanks again for your help!
 
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