Eddy Edson
Well-Known Member
- Relationship to Diabetes
- Type 2
for weight loss and metabolic risk factors, this time in overweight/obese subjects with impaired glucose regulation.
Background and Objectives: The aim of this study was to compare the effects of low-carbohydrate diet (LCD)
versus low-fat diet (LFD) on weight loss, glycemic control and metabolic risk factors in individuals with impaired glucose regulation (IGR) after 10-week intervention. Methods and Study
Design: In this 10-week randomized controlled trial, 90 obese/overweight adults with IGR were randomly assigned to consume either lowcarbohydrate diet (20%-25% energy from carbohydrates, 30%-45% energy from fat, 40%-45% energy from protein), or low-fat diet (40%-55% energy from carbohydrates, 20%-30% energy from fat, 20%-30% energy from
protein), or heath education (HE) group. The anthropometry and body composition were collected at baseline,
week 4, week 8 and week 10. The glycemia and metabolic indicators were assessed at baseline and week 10.
Results: A total of 69 participants (mean±SE age: 39.2±1.0 years, 72.5% women) completed the intervention and
were included in the final analysis. At week 10, all three groups presented similar mean reduction in weight (LCD:
5.80±0.6 kg; LFD: 6.36±0.57 kg; HE: 4.49±0.98 kg), and fasting blood glucose (LCD: 0.73±0.13 mmol/L; LFD:
0.84±0.17 mmol/L; HE: 0.58±0.14 mmol/L). Additionally, there were no differences in the improvements of TG
and liver function markers between diets, the low-fat diet exhibited more favorable effects on TC level.
Conclusions: Both diets achieved similar weight loss, fasting glucose, and insulin reduction in short-term, suggesting
each diet pattern could be an effective strategy for the prediabetes management
Background and Objectives: The aim of this study was to compare the effects of low-carbohydrate diet (LCD)
versus low-fat diet (LFD) on weight loss, glycemic control and metabolic risk factors in individuals with impaired glucose regulation (IGR) after 10-week intervention. Methods and Study
Design: In this 10-week randomized controlled trial, 90 obese/overweight adults with IGR were randomly assigned to consume either lowcarbohydrate diet (20%-25% energy from carbohydrates, 30%-45% energy from fat, 40%-45% energy from protein), or low-fat diet (40%-55% energy from carbohydrates, 20%-30% energy from fat, 20%-30% energy from
protein), or heath education (HE) group. The anthropometry and body composition were collected at baseline,
week 4, week 8 and week 10. The glycemia and metabolic indicators were assessed at baseline and week 10.
Results: A total of 69 participants (mean±SE age: 39.2±1.0 years, 72.5% women) completed the intervention and
were included in the final analysis. At week 10, all three groups presented similar mean reduction in weight (LCD:
5.80±0.6 kg; LFD: 6.36±0.57 kg; HE: 4.49±0.98 kg), and fasting blood glucose (LCD: 0.73±0.13 mmol/L; LFD:
0.84±0.17 mmol/L; HE: 0.58±0.14 mmol/L). Additionally, there were no differences in the improvements of TG
and liver function markers between diets, the low-fat diet exhibited more favorable effects on TC level.
Conclusions: Both diets achieved similar weight loss, fasting glucose, and insulin reduction in short-term, suggesting
each diet pattern could be an effective strategy for the prediabetes management