I have been looking at various research, seems that many with T1/LADA have GAD antibodies, which destroy the enzyme GAD which the body uses to create GABA. This in turn is needed for normal blood glucose function, amongst other things (e.g. low GABA is associated with anxiety and insomnia). "The GAD enzyme is primarily produced by the islet cells of the pancreas. It is the enzyme responsible for forming GABA".
So therefore people with GAD antibodies have low GABA levels, so why aren't they given a GABA supplement to compensate? The body is depleting GABA by the autoimmune process, but you can buy GABA supplements to put it back in, at least to an extent, why aren't they used? Mouse studies have shown this helps to preserve beta cell function and insulin production.
There seems some uncertainty about whether GAD antibodies go away after they have finished destroying the pancreas cells, but whether they do or not surely some GABA would be beneficial if the body is unable to produce it any more?
So therefore people with GAD antibodies have low GABA levels, so why aren't they given a GABA supplement to compensate? The body is depleting GABA by the autoimmune process, but you can buy GABA supplements to put it back in, at least to an extent, why aren't they used? Mouse studies have shown this helps to preserve beta cell function and insulin production.
There seems some uncertainty about whether GAD antibodies go away after they have finished destroying the pancreas cells, but whether they do or not surely some GABA would be beneficial if the body is unable to produce it any more?
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