some scientists suggest that spikes cause inflammation at the cell level and may cause future complications but as Northerner says, the jury is still out. So here is some info from another point of view, it is though
only really applicable to type 1.
The DCCT followed type 1s for 10 years and was then extended for another 5. During the trial quarterly HbA1cs were taken and, at the same time, the subjects had 7 fingerprick blood glucose tests taken during the day then analysed in a lab. Not the best evidence (no continuous monitoring then) but the best we have.
Eric Kilpatrick has analysed this data and writen several papers on it. Here are some of his conclusions (taken from a powerpoint presentation.
Obviously the results showed that some people had wide variations during the day, others a more stable profile.
Do 2 patients with the same MBG (mean blood glucose) but different variability have the same HbA1c?
Yes (though I think this is just to make a point there are some things that mean that this may vary between two people, HM)
Do 2 patients with the same MBG but different variability have the same risk of retinopathy?
Yes
Does increasing glucose variability lead to:
? A large increase in retinopathy risk
? A small increase in retinopathy risk
? No increase in retinopathy risk
The mean blood glucose determines the HbA1c, no matter how the mean is arrived at.
The mean blood glucose value determines diabetes microvascular complication risk, no matter how the mean is arrived at.
In other words the daily ups and downs don't ,according to Kilpatrick and the DCCT data, make a difference , what does matter is the overall average. He gives a similar breakdown for macrovascular complications, athough here the best predictor is actually the daily average and not the HbA1c (there are reasons for this, but I won't try to explain)
http://www.york.ac.uk/healthsciences/diabetes/2008conf/ekilpatrick.pdf
Its not mentioned during this presentation but elsewhere Kipatrick using the same data found that variability between HbA1cs (ie big variations in HbA1c rather than short term daily changes)
is implicated in potential complications.
http://care.diabetesjournals.org/content/31/11/2198.full.pdf+html
I think that the best thing that any of us can do is to try to keep our levels on as even a keel as possible, watching for those spikes and attempting to do something about them, aiming for a reasonable, but not necessarily too low HbA1c. This evidence doesn't back up the doom and gloom merchants who scare the life out of people for having short term spikes above 140mg/dl /7.7mmol (or even as I read on one forum yesterday110mg/dl /6.1mmol
😱) .