Weekly insulin helps patients with type 2 diabetes achieve similar blood sugar control to daily insulin

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Northerner

Northerner

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A new once-weekly basal insulin injection demonstrated similar efficacy and safety and a lower rate of low blood sugar episodes compared with a daily basal insulin, according to a phase 2 clinical trial. The study results, which will be presented at ENDO 2021, the Endocrine Society's annual meeting, compared an investigational drug called basal insulin Fc (BIF) with insulin degludec, a commercially available long-lasting daily insulin, in patients with type 2 diabetes.

"These study results demonstrate that BIF has promise as a once-weekly basal insulin and could be an advancement in insulin therapy," said Juan Frias, M.D., the study's principal investigator and the medical director of the National Research Institute in Los Angeles, Calif.

www.sciencedaily.com

Weekly insulin helps patients with type 2 diabetes achieve similar blood sugar control to daily insulin

A new once-weekly basal insulin injection demonstrated similar efficacy and safety and a lower rate of low blood sugar episodes compared with a daily basal insulin, according to a phase 2 clinical trial. The study results compared an investigational drug called basal insulin Fc (BIF) with...
www.sciencedaily.com
 
Northerner said:
A new once-weekly basal insulin injection demonstrated similar efficacy and safety and a lower rate of low blood sugar episodes compared with a daily basal insulin, according to a phase 2 clinical trial. The study results, which will be presented at ENDO 2021, the Endocrine Society's annual meeting, compared an investigational drug called basal insulin Fc (BIF) with insulin degludec, a commercially available long-lasting daily insulin, in patients with type 2 diabetes.

"These study results demonstrate that BIF has promise as a once-weekly basal insulin and could be an advancement in insulin therapy," said Juan Frias, M.D., the study's principal investigator and the medical director of the National Research Institute in Los Angeles, Calif.

www.sciencedaily.com

Weekly insulin helps patients with type 2 diabetes achieve similar blood sugar control to daily insulin

A new once-weekly basal insulin injection demonstrated similar efficacy and safety and a lower rate of low blood sugar episodes compared with a daily basal insulin, according to a phase 2 clinical trial. The study results compared an investigational drug called basal insulin Fc (BIF) with...
www.sciencedaily.com
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I think this is the same as here, @Northerner .
forum.diabetes.org.uk

Once a week basal insulin shows promise compared with daily basal

A new once-weekly basal insulin injection demonstrated similar efficacy and safety and a lower rate of low blood sugar episodes compared with a daily basal insulin, according to a phase 2 clinical trial. https://www.eurekalert.org/pub_releases/2021-03/tes-wih031621.php PLEASE NOTE: I HAVE...
forum.diabetes.org.uk forum.diabetes.org.uk
 
The big problem with ultra long lasting insulins is that once they are in, you can’t get them out.

On a smaller scale, my diabetes control was getting more and more difficult using Lantus for that reason. I needed a more variable basal, so split dose Levemir was the route to take. (At that time, I was offered a pump, but the clinic was two days travel there and back)

I don’t suppose it’s that much different for T2s who have to use insulin. It might even be more difficult if they are producing any insulin of their own. Or if they get some bug or other - or, say, are struck with a course of high dose steroids for asthma.

And defining better control using the single parameter of fewer hypoglycaemic episodes is daft. If your BG runs along at a cheery 12 you won’t get hypoglycaemic, but it’s not good control.
 
mikeyB said:
The big problem with ultra long lasting insulins is that once they are in, you can’t get them out.

On a smaller scale, my diabetes control was getting more and more difficult using Lantus for that reason. I needed a more variable basal, so split dose Levemir was the route to take. (At that time, I was offered a pump, but the clinic was two days travel there and back)

I don’t suppose it’s that much different for T2s who have to use insulin. It might even be more difficult if they are producing any insulin of their own. Or if they get some bug or other - or, say, are struck with a course of high dose steroids for asthma.

And defining better control using the single parameter of fewer hypoglycaemic episodes is daft. If your BG runs along at a cheery 12 you won’t get hypoglycaemic, but it’s not good control.
Click to expand...
My new consultant here in Harrogate tried to persuade me I should have some levemir as a standby to prevent overnight highs, should I get ill. I argued against it for precisely this reason - if my body began recovering overnight I would undoubtedly drop dangerously low, a greater problem in my view.
 
I am sure glad I am no longer down as T2 as I would hate to be on such a long lasting insulin .
Having been on a Basal and bolus Insulin for a few years I cringed when I read the first post , for all the reasons stated by @mikeyB stated .
It doesn’t bear thinking about if Basal needs suddenly go down as mine seem to have done .
 
Northerner said:
My new consultant here in Harrogate tried to persuade me I should have some levemir as a standby to prevent overnight highs, should I get ill. I argued against it for precisely this reason - if my body began recovering overnight I would undoubtedly drop dangerously low, a greater problem in my view.
Click to expand...
Spot on .
Running a bit high at night is imo safer than night hypo’s
 
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