Vegetable omega-3 triffic for heart failure risk

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Eddy Edson

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Relationship to Diabetes
Type 2

Big effects seen in this study, so keep eating those chia seeds.

Abstract


Background

There is an urgent need for cost-effective strategies to promote quality of life in patients with heart failure (HF). Several studies reported benefits in HF prognosis for marine omega-3 fatty acids and plant-based dietary patterns.

Objectives

The aim of this study was to explore whether dietary alpha-linolenic acid (ALA), the main plant omega-3, relates to a better HF prognosis.

Methods

ALA was determined in serum phospholipids (which reflect long-term dietary ALA intake and metabolism) by gas chromatography in 905 ambulatory patients with HF caused by different etiologies.

Results

After a median follow-up of 2.4 years (range: 0.02-3 years), 140 all-cause deaths, 85 cardiovascular (CV) deaths, and 141 first HF hospitalizations (composite of all-cause death and first HF hospitalization, n = 238) were documented. Using Cox regression analyses, we observed that, compared with patients at the lowest quartile of ALA in serum phospholipids (Q1), those at the 3 upper quartiles (Q2-Q4) exhibited a reduction in the risk of composite of all-cause death and first HF hospitalization (HR: 0.61; 95% CI: 0.46-0.81). Statistically significant reductions were observed for all-cause death (HR: 0.58; 95% CI: 0.41-0.82), CV death (HR: 0.51; 95% CI: 0.32-0.80), first HF hospitalization (HR: 0.58; 95% CI: 0.40-0.84), and the composite of CV death and HF hospitalization (HR: 0.58; 95% CI: 0.42-0.79).

Conclusions

HF patients with bottom 25% ALA levels in serum phospholipids had a worse prognosis during a mid-term follow-up compared with those with the highest levels. This might be a target population in whom to test dietary ALA-rich interventions to promote quality of life.
 
Don't know why they picked on vegetable Omega-3. There's plenty of Omega 3 in oily fish, and particularly in cod liver oil. As you have to sign in to see the full report, there is no evidence to show who funded this report. As Omega-3 is identical in animals and plants one assumes the benefit applies to both.
 
Don't know why they picked on vegetable Omega-3.
I assume it's because oily fish are an accepted thing, so it's useful to know whether Omega-3 from plant sources (presumably cheaper and more sustainable) is as good.
 
I assume it's because oily fish are an accepted thing, so it's useful to know whether Omega-3 from plant sources (presumably cheaper and more sustainable) is as good.

The other issue with oily fish is they are an easily farmed cash crop now, and a lot of the pellet feed is made from the remnants of processing the fish.
This has led to a concentration in pollutants and chemicals in the fish themselves, leading to advice to limit the amount you eat.
 
"Conflict of interest statement
Funding Support and Author Disclosures This work was supported by CIBER Cardiovascular (CB16/11/00403) projects, as a part of the National R&D&I Plan, and it was co-funded by ISCIII-Sub-Directorate General for Research Assessment and Promotion and the European Regional Development Fund. The funding agencies had no involvement in the study design, data collection, analyses, and interpretation of the data or writing of the manuscript. Dr Sala-Vila has received research funding through his institution and support to attend professional meetings from the California Walnut Commission. Dr Bayés-Genís has received personal fees from AstraZeneca, Vifor-Fresenius, Novartis, Boehringer Ingelheim, Abbott, Roche Diagnostics, and Critical Diagnostics. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose."


Clearly not fish feed suppliers?
 
Don't know why they picked on vegetable Omega-3. There's plenty of Omega 3 in oily fish, and particularly in cod liver oil. As you have to sign in to see the full report, there is no evidence to show who funded this report. As Omega-3 is identical in animals and plants one assumes the benefit applies to both.
They are not identical.

As I understand it, the usual story is that omega-3 in the form of ALA from plants only converts a bit into the types of omega-3 (EPA and another) you get from fish & which seem to be beneficial to heart health.

But this study supports the idea that ALA is also good for the heart. Obviously useful info if true for vegetarians or people who just don't est much fish.
 
As always, the relevant NIH fact sheet is a convenient summary: https://ods.od.nih.gov/factsheets/Omega3FattyAcids-HealthProfessional/

Relevant here:

The potential health benefits of consuming omega-3s are the focus of a great deal of scientific research. By far, the majority of research has focused on EPA and DHA from foods (e.g., fish) and/or dietary supplements (e.g., fish oil) as opposed to ALA from plant-based foods.

So this study is an attempt to partly fill that gap.
 
Just a question - is there much ALA in walnuts perchance?
 
Just a question - is there much ALA in walnuts perchance?
Indeedy! If you refer to that supplement info fact sheet I linked, the ranking goes: flx seed oil #1, chia seeds #2, walnuts #3.

EDIT: Also just to point out that flaxseed oil tastes like pox and whole flaxseeds taste like grass, so they don't really count 🙂

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Some of the funding for one of those trials came from the Walnut Association or some such organisation. I always start smelling a rodent when I notice such things, bearing in mind The Grain Board of America and one Ancel Keyes .....
 
bearing in mind The Grain Board of America and one Ancel Keyes .....
Sorry, but that's just Zoey Harcombe-level crap. If you wanted to see why all of the anti-Keys charlatanism is in fact crap there are about a zillion easy to find take-downs from actual experts.
 
Some of the funding for one of those trials came from the Walnut Association or some such organisation. I always start smelling a rodent when I notice such things, bearing in mind The Grain Board of America and one Ancel Keyes .....

Who else would pay?
It's not like Kerrygold or The Beef and Lamb Marketing Council would be interested in funding any studies on the benefits of polyunsaturated fatty acids?
Or is the implication that any research now must be biased if there may be any benefits shown to any one who contributed to it?

I don't find it odd it walnut growers wake up and think " oily fish is good for you, it contains polyunsaturated fatty acids.
Walnuts contain polyunsaturated fatty acids, let's do a bit of research on them as well"
That's just common sense, and understanding of their commercial product.
And yes, it may turn out to be good marketing, so also a good investment.
Which is also common sense.

It's the one book self publishing crackpots nowadays, full of internet theories that just go around the usual circle that need to be ignored.
If the walnut growers published their own study, then the peanut growers agreed, then I'd smell a rat.
 
Who else would pay?
It's not like Kerrygold or The Beef and Lamb Marketing Council would be interested in funding any studies on the benefits of polyunsaturated fatty acids?
Or is the implication that any research now must be biased if there may be any benefits shown to any one who contributed to it?

I don't find it odd it walnut growers wake up and think " oily fish is good for you, it contains polyunsaturated fatty acids.
Walnuts contain polyunsaturated fatty acids, let's do a bit of research on them as well"
That's just common sense, and understanding of their commercial product.
And yes, it may turn out to be good marketing, so also a good investment.
Which is also common sense.

It's the one book self publishing crackpots nowadays, full of internet theories that just go around the usual circle that need to be ignored.
If the walnut growers published their own study, then the peanut growers agreed, then I'd smell a rat.
It's lazy and not smart to dismiss research just because it's industry funded without digging into it ... but on the other hand the California Walnut Commission which has funded "attendance at professional events" by one of the researchers for this paper, has funded a whole lot of other studies, some also involving him: https://walnuts.org/health-professionals/health-research/

(CWC is a California state entity funded by a mandatory levy on growers, covering about 100% of US production.)

FWIW I get the impression that it's genuine good quality research - eg not just probably useless single food studies focusing only on walnuts but general research on ALA etc. But there are obvious CoI's which need to be kept in mind. But then there are with most research, one way or another.
 
Sorry, but that's just Zoey Harcombe-level crap. If you wanted to see why all of the anti-Keys charlatanism is in fact crap there are about a zillion easy to find take-downs from actual experts.
What do you expect from a woman my age who's been involved with diabetes forums for as long as I have? I don't believe DUK had the same opinion as you otherwise she wouldn't have written a regular column in Balance for some time.

Plus I didn't say anything about the research results being iffy - or that I didn't believe them - and God knows that if 'interested parties' didn't help fund research, there'd be far less research generally, which isn't a good thing for the world at large.
 
It's lazy and not smart to dismiss research just because it's industry funded without digging into it ... but on the other hand the California Walnut Commission which has funded "attendance at professional events" by one of the researchers for this paper, has funded a whole lot of other studies, some also involving him: https://walnuts.org/health-professionals/health-research/

(CWC is a California state entity funded by a mandatory levy on growers, covering about 100% of US production.)

FWIW I get the impression that it's genuine good quality research - eg not just probably useless single food studies focusing only on walnuts but general research on ALA etc. But there are obvious CoI's which need to be kept in mind. But then there are with most research, one way or another.

All research has to be funded by someone.
It's not realistic to expect that there won't be interested parties involved, or researchers that have an interest in a subject reappearing in similar studies.
I'd expect to see more on this to be honest, it's a good plug for walnuts, and I would expect the same researchers to be financed for a follow on study.
It's also chicken and egg, as a researcher, did he approach financiers he could realistically expect funds from, or did the walnut industry commission a study with people who already had some standing in the field?
 
What do you expect from a woman my age who's been involved with diabetes forums for as long as I have? I don't believe DUK had the same opinion as you otherwise she wouldn't have written a regular column in Balance for some time.

Plus I didn't say anything about the research results being iffy - or that I didn't believe them - and God knows that if 'interested parties' didn't help fund research, there'd be far less research generally, which isn't a good thing for the world at large.
Sorry, it won't stop raining here & it's put me in a foul mood. But ... she really had a column? Geebus!
 
Sorry, it won't stop raining here & it's put me in a foul mood. But ... she really had a column? Geebus!

Nothing recently that shows in the search.
I think they went their separate ways a while ago.
It would be interesting to read what her approach was then though.
 
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