Northerner
Admin (Retired)
- Relationship to Diabetes
- Type 1
Results from the Phase 2 trial of Mesoblast's proprietary adult stem cells in type 2 diabetes patients have been presented by Jay S. Skyler, M.D., on behalf of study investigators, at the Scientific Sessions of the 74th American Diabetes Association annual meeting held June 13-17 in San Francisco, USA. The annual meeting is the largest diabetes conference in the world, bringing together nearly 18,000 participants, including more than 14,000 clinicians and researchers from 118 countries.
Type 2 diabetes and its complications are considered to have an underlying immunological component associated with excessive pro-inflammatory cytokines, and the immunomodulatory properties of Mesoblast's Mesenchymal Precursor Cells (MPCs) provided the rationale for conducting the study.
The Phase 2 randomized, single-blind, placebo-controlled, dose escalation trial was conducted across 18 sites in the United States. The trial evaluated the effects of a single intravenous infusion of 0.3, 1.0 or 2.0 million MPCs/kg or placebo over 12 weeks in 61 patients who were inadequately controlled on metformin alone or with one other glucose-lowering agent. Mean diabetes duration was 10 years.
http://online.wsj.com/article/PR-CO-20140618-915267.html
Type 2 diabetes and its complications are considered to have an underlying immunological component associated with excessive pro-inflammatory cytokines, and the immunomodulatory properties of Mesoblast's Mesenchymal Precursor Cells (MPCs) provided the rationale for conducting the study.
The Phase 2 randomized, single-blind, placebo-controlled, dose escalation trial was conducted across 18 sites in the United States. The trial evaluated the effects of a single intravenous infusion of 0.3, 1.0 or 2.0 million MPCs/kg or placebo over 12 weeks in 61 patients who were inadequately controlled on metformin alone or with one other glucose-lowering agent. Mean diabetes duration was 10 years.
http://online.wsj.com/article/PR-CO-20140618-915267.html