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- Relationship to Diabetes
- Type 1
Researchers at Cedars-Sinai's Maxine Dunitz Neurosurgical Institute have found that a blood vessel-building gene boosts the ability of human bone marrow stem cells to sustain pancreatic recovery in a laboratory mouse model of insulin-dependent diabetes.
The findings, published in a PLOS ONE article of the Public Library of Science, offer new insights on mechanisms involved in regeneration of insulin-producing cells and provide new evidence that a diabetic's own bone marrow one day may be a source of treatment. Scientists began studying bone marrow-derived stem cells for pancreatic regeneration a decade ago. Recent studies involving several pancreas-related genes and delivery methods ? transplantation into the organ or injection into the blood ? have shown that bone marrow stem cell therapy could reverse or improve diabetes in some laboratory mice. But little has been known about how stem cells affect beta cells ? pancreas cells that produce insulin ? or how scientists could promote sustained beta cell renewal and insulin production.
http://medicalxpress.com/news/2012-10-bone-marrow-stem-cell-therapy.html
The findings, published in a PLOS ONE article of the Public Library of Science, offer new insights on mechanisms involved in regeneration of insulin-producing cells and provide new evidence that a diabetic's own bone marrow one day may be a source of treatment. Scientists began studying bone marrow-derived stem cells for pancreatic regeneration a decade ago. Recent studies involving several pancreas-related genes and delivery methods ? transplantation into the organ or injection into the blood ? have shown that bone marrow stem cell therapy could reverse or improve diabetes in some laboratory mice. But little has been known about how stem cells affect beta cells ? pancreas cells that produce insulin ? or how scientists could promote sustained beta cell renewal and insulin production.
http://medicalxpress.com/news/2012-10-bone-marrow-stem-cell-therapy.html