Sleep-Deprived Mice Show Connection With Diabetes, Age

[Northerner]

Sleep, or the lack of it, seems to affect just about every aspect of human physiology. Yet, the molecular pathways through which sleep deprivation wreaks its detrimental effects on the body remain poorly understood. Although numerous studies have looked at the consequences of sleep deprivation on the brain, comparatively few have directly tested its effects on peripheral organs.

During sleep deprivation cells upregulate the UPR -- the unfolded protein response -- a process where misfolded proteins get refolded or degraded.

http://www.sciencedaily.com/releases/2013/12/131211185215.htm