Northerner
Admin (Retired)
- Relationship to Diabetes
- Type 1
London, Dec 8 (PTI) British scientists have made an important discovery about the mechanism controlling the body''s ''fat switch'', shedding new light on the understanding of how proteins regulate appetite control and insulin secretion.
The research, led by Professor Victor Zammit, Head of Metabolic and Vascular Health at Warwick Medical School, found that the enzyme known as ''Carnitine palmitoyltransferase 1A'' (CPT1) has a "switch" which is thrown depending on the composition and curvature of its cellular membrane.
This is the first time such a mechanism has been described and may possibly be unique, reflecting the importance of this protein to cellular function, a release from the University of Warwick said.
http://news.in.msn.com/international/article.aspx?cp-documentid=5662215
Not really sure why you would want to develop a drug to prevent DKA when you could just give insulin
Whilst you might not want the ketones, you'd still need the energy from metabolising fat if there was a shortage of insulin, until more insulin could be administered.
The research, led by Professor Victor Zammit, Head of Metabolic and Vascular Health at Warwick Medical School, found that the enzyme known as ''Carnitine palmitoyltransferase 1A'' (CPT1) has a "switch" which is thrown depending on the composition and curvature of its cellular membrane.
This is the first time such a mechanism has been described and may possibly be unique, reflecting the importance of this protein to cellular function, a release from the University of Warwick said.
http://news.in.msn.com/international/article.aspx?cp-documentid=5662215
Not really sure why you would want to develop a drug to prevent DKA when you could just give insulin
Whilst you might not want the ketones, you'd still need the energy from metabolising fat if there was a shortage of insulin, until more insulin could be administered.