Scientists characterize the imbalanced gut bacteria of patients with myocardial infarction, angina and heart failure

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In two publications in Nature Medicine, a European-Israeli team of researchers show how major disturbances occur in the gut microbiome of patients suffering from heart disease. Given this latest evidence from microbiome research, one of the senior lead researchers, Professor Oluf Pedersen from the University of Copenhagen, calls for stronger and more focused public health initiatives to prevent or delay these common diseases that are a leading cause of premature death worldwide through plant-based and energy-controlled diet, avoidance of smoking and compliance with daily exercise.

The human gut contains trillions of bacteria, collectively called the gut microbiome, which may have positive and negative effects on human health. When in balance they function as an inner chemistry factory producing numerous compounds that promote good health. However, an unhealthy lifestyle -- poor diet, smoking, lack of physical activity or disease -- can disrupt the balance, leading the microbiome to instead produce compounds that may trigger multiple non-communicable chronic disorders in people at high genetic risk, including myocardial infarction, angina or heart failure.
Scientists have already discovered that the gut microbiome is altered in people with chronic heart disease. They subsequently identified compounds that are produced by the diseased microbiome, for instance a bacterial compound called trimethylamine (TMA) that after modification in the liver of the human host causes arteriosclerosis.


Read 'Gut' by Giulia Enders! 🙂
 
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