Retinal vascular occlusion after COVID-19 vaccination

[Amity Island]

We excluded individuals with a history of retinal vascular occlusion or those who used any systemic medication that could potentially affect blood coagulation prior to vaccination. To compare the risk of retinal vascular occlusion, we employed multivariable-adjusted Cox proportional hazards models after performing a 1:1 propensity score matching between the vaccinated and unvaccinated cohorts. Individuals with COVID-19 vaccination had a higher risk of all forms of retinal vascular occlusion in 2 years after vaccination, with an overall hazard ratio of 2.19 (95% confidence interval 2.00–2.39).

Risk assessment of retinal vascular occlusion after COVID-19 vaccination - npj Vaccines

Coronavirus disease 2019 (COVID-19) vaccines are associated with several ocular manifestations. Emerging evidence has been reported; however, the causality between the two is debatable. We aimed to investigate the risk of retinal vascular occlusion after COVID-19 vaccination. This retrospective...

www.nature.com

A video explaining this here.

 

[everydayupsanddowns]

This study is also featured here I think:

Risk of New Retinal Vascular Occlusion After mRNA COVID-19 Vaccination

www.practiceupdate.com

IMPORTANCE​

New-onset retinal vascular occlusion (RVO) occurring acutely after messenger RNA (mRNA) COVID-19 vaccination has been described in recent literature. Because RVO can cause vision loss or blindness, an epidemiologic investigation evaluating this potential association is of great importance to public health.

TAKE-HOME MESSAGE​

• An analysis of a large dataset of individuals who received the mRNA COVID-19 vaccination revealed that the incidence rate of patients experiencing retinal vascular occlusion (RVO) within 21 days of the first dose of mRNA COVID-19 vaccination was 0.003%, with a relative risk comparable to that occurring after influenza or pertussis (Tdap) vaccinations. No evidence was found to suggest that mRNA COVID-19 vaccination was associated with newly diagnosed RVO.
• This information could help inform individuals with vaccine hesitancy.

CONCLUSIONS AND RELEVANCE​

The findings of this study suggest that RVO diagnosed acutely after mRNA COVID-19 vaccination occurs extremely rarely at rates similar to those of 2 different historically used vaccinations, the influenza and Tdap vaccines. No evidence suggesting an association between the mRNA COVID-19 vaccination and newly diagnosed RVO was found.

 

[Amity Island]

This study is also featured here I think:

Risk of New Retinal Vascular Occlusion After mRNA COVID-19 Vaccination

www.practiceupdate.com

IMPORTANCE​

New-onset retinal vascular occlusion (RVO) occurring acutely after messenger RNA (mRNA) COVID-19 vaccination has been described in recent literature. Because RVO can cause vision loss or blindness, an epidemiologic investigation evaluating this potential association is of great importance to public health.

TAKE-HOME MESSAGE​

• An analysis of a large dataset of individuals who received the mRNA COVID-19 vaccination revealed that the incidence rate of patients experiencing retinal vascular occlusion (RVO) within 21 days of the first dose of mRNA COVID-19 vaccination was 0.003%, with a relative risk comparable to that occurring after influenza or pertussis (Tdap) vaccinations. No evidence was found to suggest that mRNA COVID-19 vaccination was associated with newly diagnosed RVO.
• This information could help inform individuals with vaccine hesitancy.

CONCLUSIONS AND RELEVANCE​

The findings of this study suggest that RVO diagnosed acutely after mRNA COVID-19 vaccination occurs extremely rarely at rates similar to those of 2 different historically used vaccinations, the influenza and Tdap vaccines. No evidence suggesting an association between the mRNA COVID-19 vaccination and newly diagnosed RVO was found.

Hi Mike,

Are they comparing like with like? The study was 2 years after vaccination the other 21 days after vaccination?

 

[bulkbiker]

This study is also featured here I think:

Risk of New Retinal Vascular Occlusion After mRNA COVID-19 Vaccination

www.practiceupdate.com

IMPORTANCE​

New-onset retinal vascular occlusion (RVO) occurring acutely after messenger RNA (mRNA) COVID-19 vaccination has been described in recent literature. Because RVO can cause vision loss or blindness, an epidemiologic investigation evaluating this potential association is of great importance to public health.

TAKE-HOME MESSAGE​

• An analysis of a large dataset of individuals who received the mRNA COVID-19 vaccination revealed that the incidence rate of patients experiencing retinal vascular occlusion (RVO) within 21 days of the first dose of mRNA COVID-19 vaccination was 0.003%, with a relative risk comparable to that occurring after influenza or pertussis (Tdap) vaccinations. No evidence was found to suggest that mRNA COVID-19 vaccination was associated with newly diagnosed RVO.
• This information could help inform individuals with vaccine hesitancy.

CONCLUSIONS AND RELEVANCE​

The findings of this study suggest that RVO diagnosed acutely after mRNA COVID-19 vaccination occurs extremely rarely at rates similar to those of 2 different historically used vaccinations, the influenza and Tdap vaccines. No evidence suggesting an association between the mRNA COVID-19 vaccination and newly diagnosed RVO was found.

Where is the unvaccinated control group?
What a pointless "study".

 

[Amity Island]

Where is the unvaccinated control group?
What a pointless "study".

I'm certain that had they of had their way, there'd be no one left in the world to form a control group (think about that for a moment). Thankfully (let's just be grateful), millions caught the virus and millions didn't, many of these then stuck with their own acquired and innate immunity therein.

 

[Bruce Stephens]

Where is the unvaccinated control group?

They were comparing against the baseline rate, I think, which doesn't seem a terrible approach. More problematic is @Amity Island's point that they're only looking at 21 days vs 2 years. (Though I don't know of an obvious mechanism for long term effect.)

 

[bulkbiker]

They were comparing against the baseline rate, I think, which doesn't seem a terrible approach. More problematic is @Amity Island's point that they're only looking at 21 days vs 2 years. (Though I don't know of an obvious mechanism for long term effect.)

Doesn't read like that

" The appearance of a new-encounter diagnosis of RVO within 21 days of the mRNA COVID-19 vaccination was the primary outcome. Historical comparison cohorts of patients receiving influenza and Tdap vaccinations allowed for evaluation of the RRs for RVO."

No mention of the unjabbed being included or maybe the unjabbed don't suffer from the problem.

 

[Bruce Stephens]

Doesn't read like that

You're correct.

No mention of the unjabbed being included or maybe the unjabbed don't suffer from the problem.

If one wanted a control group, choosing people who'd had some different vaccination seems sensible to me. I don't know why they chose the one they did.

 

[Bruce Stephens]

We excluded individuals with a history of retinal vascular occlusion or those who used any systemic medication that could potentially affect blood coagulation prior to vaccination. To compare the risk of retinal vascular occlusion, we employed multivariable-adjusted Cox proportional hazards models after performing a 1:1 propensity score matching between the vaccinated and unvaccinated cohorts. Individuals with COVID-19 vaccination had a higher risk of all forms of retinal vascular occlusion in 2 years after vaccination, with an overall hazard ratio of 2.19 (95% confidence interval 2.00–2.39).

Risk assessment of retinal vascular occlusion after COVID-19 vaccination - npj Vaccines

Coronavirus disease 2019 (COVID-19) vaccines are associated with several ocular manifestations. Emerging evidence has been reported; however, the causality between the two is debatable. We aimed to investigate the risk of retinal vascular occlusion after COVID-19 vaccination. This retrospective...

www.nature.com

A video explaining this here.

Here's a video arguing that the paper is significantly flawed and offering another few which failed to find a link: