Northerner
Admin (Retired)
- Relationship to Diabetes
- Type 1
A study published online in the Journal of Biological Chemistry (http://www.jbc.org/content/early/2012/05/23/jbc.M112.363960) showed a new drug to treat diabetes being developed by Metabolic Solutions Development Company, LLC (MSDC), MSDC-0602, improved insulin resistance and inflammation in obese mice. These findings by researchers at Washington University School of Medicine, in collaboration with colleagues at the University of Michigan and MSDC, suggest that MSDC-0602, a novel anti-diabetic drug which is in Phase 2 clinical trials, may constitute the first in a class of next generation insulin sensitizers that appear to work through a new biochemical mechanism to treat insulin resistance and type 2 diabetes.
"Currently-approved insulin sensitizing drugs are effective but their use is limited by side effects believed to be caused by the over-activation of the peroxisome proliferator-activated receptor gamma (PPARg)," said Brian N. Finck, PhD, Research Assistant Professor in Medicine, Division of Geriatrics & Nutritional Science, Washington University School of Medicine. "Our findings provide the framework for the discovery and development of a new class of insulin sensitizers that can operate independent of the activation of PPARg."
http://www.healthcareglobal.com/pre...hrough-a-new-mechanism-to-treat-root-cause-of
"Currently-approved insulin sensitizing drugs are effective but their use is limited by side effects believed to be caused by the over-activation of the peroxisome proliferator-activated receptor gamma (PPARg)," said Brian N. Finck, PhD, Research Assistant Professor in Medicine, Division of Geriatrics & Nutritional Science, Washington University School of Medicine. "Our findings provide the framework for the discovery and development of a new class of insulin sensitizers that can operate independent of the activation of PPARg."
http://www.healthcareglobal.com/pre...hrough-a-new-mechanism-to-treat-root-cause-of