Research could result in new approach to prevent diabetes-induced birth defects

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Northerner

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A research team at the University of Maryland School of Medicine has identified a cell signaling pathway which plays a significant role in causing developmental defects of the fetal spinal cord and brain in babies of women with diabetes. Using an animal model of disease, the team's results point to a potential new therapeutic target for preventing these defects in pregnant women having preexisting diabetes. The results of this study are published in the August 27th issue of Science Signaling.

"Providing the best possible care for women before and during early pregnancy is a significant challenge because the first trimester is such a crucial time of development, and many women may not be aware that they are pregnant," says Dean E. Albert Reece, M.D., Ph.D., M.B.A., vice president for medical affairs at the University of Maryland and the John Z. and Akiko K. Bowers distinguished professor and dean of the School of Medicine. "Prenatal care is especially important for women who have diabetes because research has shown that even transient increases in blood glucose can lead to serious, and sometimes life-threatening, birth defects."

http://www.sciencecodex.com/univ_of..._prevent_diabetesinduced_birth_defects-118275
 
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