Northerner
Admin (Retired)
- Relationship to Diabetes
- Type 1
Atypical antipsychotics impact metabolic risk independent of weight gain, according to a carefully-controlled laboratory monitoring study.
Olanzapine (Zyprexa) induced insulin resistance and postprandial dysregulation over less than 2 weeks in healthy volunteers before any weight gain occurred, Karen Teff, PhD, then of the University of Pennsylvania in Philadelphia, and colleagues found.
Aripiprazole (Abilify) also induced insulin resistance that didn't parallel the normal mechanisms in diabetes, without any free fatty acid or weight increase, the group reported here at the American Diabetes Association meeting.
http://www.medpagetoday.com/MeetingCoverage/ADA/40052
Olanzapine (Zyprexa) induced insulin resistance and postprandial dysregulation over less than 2 weeks in healthy volunteers before any weight gain occurred, Karen Teff, PhD, then of the University of Pennsylvania in Philadelphia, and colleagues found.
Aripiprazole (Abilify) also induced insulin resistance that didn't parallel the normal mechanisms in diabetes, without any free fatty acid or weight increase, the group reported here at the American Diabetes Association meeting.
http://www.medpagetoday.com/MeetingCoverage/ADA/40052