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- Relationship to Diabetes
- Type 1
Historically, half or more of people with type 1 diabetes develop kidney disease, which frequently progresses to kidney failure requiring hemodialysis or a kidney transplant for survival. The high rate of this diabetic complication has dropped slightly in recent years, with the advent of better ways to control blood glucose (sugar) levels and improved blood pressure drugs, "but diabetic kidney disease is still a huge problem," says Alessandro Doria, MD, PhD, MPH, Senior Investigator in Joslin Diabetes Center's Section on Genetics and Epidemiology.
Progression of kidney disease in type 1 diabetes is correlated with increased amounts of a compound in the blood called uric acid. Hoping that a drug that reduces these uric acid levels would slow the disease, Doria and his colleagues launched a multi-institution randomized clinical trial that enrolled 530 participants with type 1 diabetes and early-to-moderate kidney disease.
Results of the Preventing Early Renal Loss in Diabetes (PERL) study were just published in the New England Journal of Medicine (NEJM), the leading clinical research journal. Unfortunately, this study did not show the desired clinical benefits. "This is not the result that we wanted," says Doria, "but it does give a very clear answer to an important scientific question."
Progression of kidney disease in type 1 diabetes is correlated with increased amounts of a compound in the blood called uric acid. Hoping that a drug that reduces these uric acid levels would slow the disease, Doria and his colleagues launched a multi-institution randomized clinical trial that enrolled 530 participants with type 1 diabetes and early-to-moderate kidney disease.
Results of the Preventing Early Renal Loss in Diabetes (PERL) study were just published in the New England Journal of Medicine (NEJM), the leading clinical research journal. Unfortunately, this study did not show the desired clinical benefits. "This is not the result that we wanted," says Doria, "but it does give a very clear answer to an important scientific question."
Promising treatment to slow kidney disease doesn't prove out in clinical trial
Progression of kidney disease in type 1 diabetes is correlated with increased amounts of uric acid. A drug that reduces uric acid levels was tested in a multi-institution randomized clinical trial. Though the study did not show the desired clinical benefit, it did provide a very clear answer to...
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