Oramed oral insulin fails Phase 3 trial

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Eddy Edson

Eddy Edson

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Relationship to Diabetes
Type 2
Well nobody's ever got such a thing to work before so I'm rather flabbergasted (ie more like absolutely gobsmacked) that their earlier results were 'encouraging', frankly.

At least people are still trying which I suppose is the main thing even though the chances of finding a cure in my lifetime grow even slighter by the day.
 
I hardly think that oral insulin is any sign of a “cure”, so its failure, which is unsurprising, is not a dent in the search for a cure. Which is, of course, just as unlikely in our lifetimes as it was before this latest failure in administering insulin.
 
LOL @mikeyB - 'still' as unlikely then. Must admit, I ceased to actually expect it a very long time ago.

There again, sodding nuisance as it is, I have got used to it and I think I'd feel a bit weird were it not there!
 
trophywench said:
Well nobody's ever got such a thing to work before so I'm rather flabbergasted (ie more like absolutely gobsmacked) that their earlier results were 'encouraging', frankly.

At least people are still trying which I suppose is the main thing even though the chances of finding a cure in my lifetime grow even slighter by the day.
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I think that P1 is safety trials - so promising means that no one had any significant adverse effects, and P2 is healthy subjects - not sure what "promising" would have meant for that given that healthy subjects should just have produced a little less of their own insulin if given a small dose of insulin...
 
42istheanswer said:
I think that P1 is safety trials - so promising means that no one had any significant adverse effects, and P2 is healthy subjects - not sure what "promising" would have meant for that given that healthy subjects should just have produced a little less of their own insulin if given a small dose of insulin...
Click to expand...
You'd usually get some eficacy data from P2 but generally the trial wouldn't be big enough etc for statistical significance.
 
I gave up believing in a cure in the early 70s. In 1967 a consultant and, slightly bizarrely our greengrocer (remember them) told me there would be a cure within a year! There was also something in Tomorrow's World with Raymond Baxter but I have long forgotten one. As insulin is a protein the idea of an oral insulin for Type 1s is IMHO a load of ducking crup! The main hope for a cure is I think transplant of genetically harvested organs from pigs. I doubt we will see a cure in my lifetime now! :(
 
MikeyBikey said:
I gave up believing in a cure in the early 70s. In 1967 a consultant and, slightly bizarrely our greengrocer (remember them) told me there would be a cure within a year! There was also something in Tomorrow's World with Raymond Baxter but I have long forgotten one. As insulin is a protein the idea of an oral insulin for Type 1s is IMHO a load of ducking crup! The main hope for a cure is I think transplant of genetically harvested organs from pigs. I doubt we will see a cure in my lifetime now! :(
Click to expand...

I think the engineered pigs have passed.
It'll be an engineered one lab grown from human stem cells using mRNA technology.
 
The pigs they using did have to be euthanised when the Med School (not that many miles from Coventry) who were supporting the research, withdrew their support. We were told this by the researcher so it was true - but it was about 10 years ago anyway, so they and the research have been dead a good while now.
 
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