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- Relationship to Diabetes
- Type 1
It is well known that fat cells can influence our sensitivity to insulin. Now, researchers at Karolinska Institutet in Sweden have discovered that there are three different subtypes of mature fat cells in white adipose tissue and that it is only one of these, called AdipoPLIN, that responds to insulin. The findings may be relevant for future treatments of metabolic diseases such as Type 2 diabetes.
"These findings increase our knowledge about the function of fat tissue," says co-corresponding author Niklas Mejhert, researcher at the Department of Medicine, Huddinge, at Karolinska Institutet. "They show that the overall capacity of fat tissue to respond to insulin is determined by the proportion and function of a specific fat cell subtype. This could have implications for diseases such as obesity, insulin resistance and Type 2 diabetes."
In the study, which is published in the journal Cell Metabolism, the researchers identified 18 cell classes that forms clusters in white adipose tissue in humans. Of these, three constituted mature fat cells with distinct phenotypes.
"These findings increase our knowledge about the function of fat tissue," says co-corresponding author Niklas Mejhert, researcher at the Department of Medicine, Huddinge, at Karolinska Institutet. "They show that the overall capacity of fat tissue to respond to insulin is determined by the proportion and function of a specific fat cell subtype. This could have implications for diseases such as obesity, insulin resistance and Type 2 diabetes."
In the study, which is published in the journal Cell Metabolism, the researchers identified 18 cell classes that forms clusters in white adipose tissue in humans. Of these, three constituted mature fat cells with distinct phenotypes.
Only one human fat cell subtype responds to insulin stimulation
It is well known that fat cells can influence our sensitivity to insulin. Now, researchers have discovered that there are three different subtypes of mature fat cells in white adipose tissue and that it is only one of these, called AdipoPLIN, that responds to insulin. The findings may be...
www.sciencedaily.com
