Northerner
Admin (Retired)
- Relationship to Diabetes
- Type 1
For the first time, scientists at the Toronto General Research Institute showed that targeting glucagon action in the brain may be a new frontier for regulating diabetes.
An international team led by Senior Scientist Dr. Tony Lam showed how glucagon regulates the hypothalamus' control over blood sugar.
In experimental models of obesity and diabetes, researchers determined that resistance to glucagon in the brain leads to increases in blood sugar levels, a trait of these conditions. However, direct stimulation of the protein kinase A signaling pathways (PKA) in the brain bypasses the resistance and decreases blood sugar levels.
http://www.sciencedaily.com/releases/2013/05/130519145650.htm
An international team led by Senior Scientist Dr. Tony Lam showed how glucagon regulates the hypothalamus' control over blood sugar.
In experimental models of obesity and diabetes, researchers determined that resistance to glucagon in the brain leads to increases in blood sugar levels, a trait of these conditions. However, direct stimulation of the protein kinase A signaling pathways (PKA) in the brain bypasses the resistance and decreases blood sugar levels.
http://www.sciencedaily.com/releases/2013/05/130519145650.htm