Non-invasive glucose detection

[Amity Island]

Looks promising, potentially an improvement on the Libre etc?

The rising demand for non-invasive and non-enzymatic glucose sensors is driven by the objective of eliminating the need of blood pricks from body and need of enzyme free detection of glucose to diagnose diabetes mellitus. To aid this resolution, we have synthesized Ni MOF- MXene (NiBDC-MXene) hybrid material through a one-pot synthesis, which serves as a catalyst to detect salivary glucose via an extended gate field effect transistor (EGFET) method. The resulting sensor exhibits, good selectivity towards glucose over common interfering molecules such as sucrose, fructose, maltose, uric acid and ascorbic acid in a physiological condition of saliva. The fabricated electrode demonstrated good sensitivity of 685.37 μA mM-1 cm-2 with a detection range of 10 μM to 1100 μM and limit of detection (LOD) of 0.23 μM. The real-time measurements demonstrate the electrode's capability for detecting salivary glucose. Additional to EGFET measurements, scanning Kelvin probe (SKP) measurements were performed to understand the mechanism of charge transfer between the glucose and NiBDC-MXene/CP electrode. Overall, the EGFET results demonstrates the capability of sensor to detect the salivary glucose covering, hypoglycaemia, normal and hyperglycaemia.

A Step Towards Non-Invasive Diagnosis of Diabetes Mellitus Using In-Situ Synthesized MOF-MXene Hybrid Material with Extended Gate Field-Effect Transistor Integration

The rising demand for non-invasive and non-enzymatic glucose sensors is driven by the objective of eliminating the need of blood pricks from body and need of enzyme free detection of glucose to diagnose diabetes mellitus. To aid this resolution, we have synthesized Ni MOF- MXene (NiBDC-MXene)...

pubs.rsc.org

 

[everydayupsanddowns]

If it’s measuring glucose in saliva, isn’t it going to struggle after you’ve had glucose in your mouth to treat a hypo?

Interesting that they are framing it as a diagnostic device. I wonder if that means they don’t intend it to be used as a CGM?

 

[SimonP]

If it’s measuring glucose in saliva, isn’t it going to struggle after you’ve had glucose in your mouth to treat a hypo?

Yes, though if you can use sucrose it can tell the difference. However, iirc sucrose is (partially)broken down to glucose by enzymes in saliva, so ymmv...

Interesting that they are framing it as a diagnostic device. I wonder if that means they don’t intend it to be used as a CGM?

They do mention that they are single use devices in the paper, otoh they also say they can measure full range from hypo -though normal to hyper-glycemia in saliva so if they can improve the longevity of the devices (I didn't read far enough to make any comment on this aside from their statement that they are single use) then perhaps there's scope - lick my watch every 5min? 🙂

 

[Bruce Stephens]

If it’s measuring glucose in saliva, isn’t it going to struggle after you’ve had glucose in your mouth to treat a hypo?

Interesting that they are framing it as a diagnostic device. I wonder if that means they don’t intend it to be used as a CGM?

I'd guess it's early stage work, without a particular application in mind. If you can now use saliva (with this new technique), maybe looking again at tears, sweat, etc., would be worth a go.