New Ultra-Rapid-Acting Insulin Formulation

[Northerner]

BIOD-531 is an ultra-rapid-acting formulation of recombinant human insulin (RHI) at a concentration of 400 units/ml (U-400) combined with EDTA, citrate and magnesium sulfate. In the Phase 1 Study 3-150, the results of which were released in February 2014, BIOD-531 administered to non-diabetic, obese volunteers demonstrated ultra-rapid absorption and onset of action in comparison with Humalog Mix 75/25 and Humulin R U-500, and had an extended duration of action that is expected to be suitable for basal insulin needs.

http://www.diabetesincontrol.com/ar...89-new-ultra-rapid-acting-insulin-formulation

 

[Pumper_Sue]

If it's rapid acting how can it be a basal?

 

[Northerner]

If it's rapid acting how can it be a basal?

My thoughts also Wondering if the wording is important - ultrafast onset, but extended release? Although I wouldn't have thought the ultrafast bit was that advantageous?

 

[HelenM]

The account was totally garbled
How about this pearl?
•Other preclinical studies have shown that BIOD-531 has a more rapid rate of absorption and onset of action, along with a similar duration of action in patients with diabetic swine when compared against Humulin R U-500

The full report for anyone interested is here:
http://investor.biodel.com/releasedetail.cfm?ReleaseID=865429
They are claiming a rapid absorption and onset but also an extended duration of action. One injection was used to cover breakfast and lunch and they claim did so better than the mixed insulin and the u500 that they compared it with.
The trial was in people with 'moderate' insulin resistance but as it's u400 may work well for people who are very insulin resistant and normally use u500.