New ultra low insulin very early trial results

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Wendal

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Type 3c
Morning am not sure of exactly what can be posted as want to avoid any “ commercial aspects” but did think they this would be of interest to some on here although at the moment I am managing fine on Novo Rapid.

AT278 ULTRA-CONCENTRATED ULTRA-RAPID ACTING INSULIN DEMONSTRATES SUPERIORITY IN PHASE I CLINICAL TRIAL IN OVERWEIGHT AND OBESE PEOPLE WITH TYPE 2 DIABETES

I have to stress this is a phase one trial so is extremely early and a very long way from Approval with many barriers to overcome so please judge in that perspective.
But as I said earlier it may be of interest for those who need to use a lot of insulin and/ or a concentrated version to know that there is work going on in this area.
Again to repeat this is not any endorsement but simply to make people aware of the results.
Take care but please remove if this infringes any U.K. diabetes rules.
 
Interesting find @Wendal 🙂

Not heard of the manufacturer (Arecor), but a web page that Google offered suggests it can be concentrated up to u1000 (so 10x the strength of regular u100 insulins 😱 ). They also seem to be working in collaboration with Medtronic on other projects.

Imagine the precision you’d need on dosing devices!
 
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Wendal said:
PS comment on insulin pumps

Creates potential to be the first, and only, ultra-concentrated (500 U/mL) ultra-rapid insulin product enabling miniaturisation of next-generation insulin pumps
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Yes it’s a miniaturised implantable that Medtronic seem to be working on with them.
 
Amity Island said:
Mike, out of interest, how does the strength compare with natural pancreas produced insulin?
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I’m not sure I’ve ever heard any similarity drawn - I just remember hearing in a conference presentation that one of the challenges of managing diabetes with injected insulin is that we inject the wrong sort of insulin, that acts over the wrong timeframe, into the wrong place… (or something like that!)

I think initially insulins were available in a variety of strengths u40, u80 etc, and it made dosing harder. Trying to standardise most insulins at u100 (100 units per ml) was an attempt to reduce dose errors I think?

From the early extraction of pork and beef insulins I think there were various stages of purification and concentration to get to a workable subcutaneous-injectable solution?
 
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everydayupsanddowns said:
I’m not sure I’ve ever heard any similarity drawn - I just remember hearing in a conference presentation that one of the challenges of managing diabetes with injected insulin is that we inject the wrong sort of insulin, that acts over the wrong timeframe, into the wrong place… (or something like that!)

I think initially insulins were available in a variety of strengths u40, u80 etc, and it made dosing harder. Trying to standardise most insulins at u100 (100 units per ml) was an attempt to reduce dose errors I think?

From the early extraction of pork and beef insulins I think there were various stages of purification and concentration to get to a workable subcutaneous-injectable solution?
Click to expand...
If we are looking at a nano implantable pump, then I'd assume we would need an equally concentrated glucose too. Is that possible?
 
Amity Island said:
If we are looking at a nano implantable pump, then I'd assume we would need an equally concentrated glucose too. Is that possible?
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Pumps usually just do the insulin part. There are some that also pump glucagon but I think only experimental systems at present. I don't think it makes sense to talk of "concentrated glucose": once you're at 100% glucose that's as far as you can go.

I presume pumps using this extremely concentrated insulin will just need to be really, really, carefully engineered. (Unless they can make extremely concentrated smart insulin, I suppose.)
 
I wonder what the rationale is behind making something so strong. With u100 you have enough flexibility to vary the dose within reasonable bounds; with something 10x stronger I would guess you effectively have none. You go first.
 
Merluza said:
I wonder what the rationale is behind making something so strong. With u100 you have enough flexibility to vary the dose within reasonable bounds; with something 10x stronger I would guess you effectively have none. You go first.
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For some applications (like a pump that's implanted), space would really matter.
 
Merluza said:
I wonder what the rationale is behind making something so strong. With u100 you have enough flexibility to vary the dose within reasonable bounds; with something 10x stronger I would guess you effectively have none. You go first.
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More concentrated insulins seem to help a great deal where there is insulin resistance making the doses much larger - sometimes such that the volume of fluid required adversely affects the absorption of the dose itself.

I guess if your doses are generally 4-8u it’s quite different to if your doses are generally 40-80u 🙂

But yes 10x strength does see, quite extreme, and possibly connected to something else. Where there’s another requirement for reducing the volume of fluid per dose much more dramatically?
 
Bruce Stephens said:
Pumps usually just do the insulin part. There are some that also pump glucagon but I think only experimental systems at present. I don't think it makes sense to talk of "concentrated glucose": once you're at 100% glucose that's as far as you can go.

I presume pumps using this extremely concentrated insulin will just need to be really, really, carefully engineered. (Unless they can make extremely concentrated smart insulin, I suppose.)
Click to expand...
Bruce, any idea what strength pancreas insulin is? Would be nice to put into the context of artificial insulins.
 
Amity Island said:
Bruce, any idea what strength pancreas insulin is? Would be nice to put into the context of artificial insulins.
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I thought it was roughly the strength of regular insulin? That is, animal insulin or the non-analogue human insulins. I’m sure I read something about how many units the average non-diabetic person makes a day.
 
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