New path for reversing type-2 diabetes and liver fibrosis

[Northerner]

In a pair of related studies, a team of Yale researchers has found a way to reverse type-2 diabetes and liver fibrosis in mice, and has shown that the underlying processes are conserved in humans.

The studies appear in the Feb. 4 edition of Cell Reports and in the Jan. 17 edition of Nature Communications.

In the earlier study, researchers found an important connection between how the body responds to fasting and type-2 diabetes. Fasting "switches on" a process in the body in which two particular proteins, TET3 and HNF4a increase in the liver, driving up production of blood glucose. In type-2 diabetes, this "switch" fails to turn off when fasting ends, as it would in a non-diabetic person.

https://www.sciencedaily.com/releases/2020/02/200204112522.htm

 

[ColinUK]

So are they saying it’s good or bad?

 

[Drummer]

I think they are saying it is bad if diabetics fast long enough to turn on the effect, which is perhaps why I find my blood glucose levels are best when eating twice a day at 12 hour intervals - but if I do not eat first thing then my glucose levels continue to rise until I do.

 

[NotWorriedAtAll]

I think they are saying it is bad if diabetics fast long enough to turn on the effect, which is perhaps why I find my blood glucose levels are best when eating twice a day at 12 hour intervals - but if I do not eat first thing then my glucose levels continue to rise until I do.

Same thing happens with me in the morning. But if I skip lunch my blood glucose drops as one would expect and goes down to around 5 by the time the evening meal comes round.