New kind of glucagon

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fencesitter

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This may have been posted already as the idea is not brand new, but I've only just come across it. Looks interesting. A new kind of injectable glucagon that you'll be able to keep out of the fridge and use in small amounts to manage hypos:

http://xerispharma.com/html/glucagon_.html
 
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This may have been posted already as the idea is not brand new, but I've only just come across it. Looks interesting. A new kind of injectable insulin that you'll be able to keep out of the fridge and use in small amounts to manage hypos:

http://xerispharma.com/html/glucagon_.html

Have heard about the glucagon going in pumps at some point, but haven't seen any articles about it. So thanks for the info 🙂
 
Erk, another solution (the mini-pen) to a problem that doesn't exist. I can see quite clearly how they're going to market the smaller pen - it's the zero-calorie hypo fix option. Hooray. In other words, what they're saying is "You're fat because you need to eat to treat hypos! Use our magic pen and you'll still have hypos but at least now you won't get fat!"

Of course, what they don't tell you is that treating a hypo is generally about 15g of carbs or in other words, 60 calories. One or two of those a week isn't going to make you put on lots of weight. But a constant generalised feeding of your insulin will. All this does is encourage further laziness on the part of both patients and doctors to just keep relying on big insulin doses rather than look at more sensibly matching carb and insulin intake to what the person actually needs.

Plus, as we all know, hypos mainly come from making an error in judging how much insulin you need - an error which is extremely easy to make at the best of times. If someone is having lots of hypos and needs a zero-cal solution, obviously sensible injection judgement isn't their strong point. Why give that person another injection device of all things, when if they are having a hypo their judgement is already gone to pot? Surely that's just an accident waiting to happen?
 
Standard care for hypoglycaemia is NOT glucagon - it is only standard if person has not been able treat their own hypogycaemia with sweets / sugar drink, and has ended up unconscious / unable to swallow safely, which means someone else has to administer glucagon.

Agree that VERY careful labelling and use will be needed, just like for lidocaine with adrenaline which is useful for limiting bleeding into a wound, which makes seeing to suture a wound more difficult, but must not be used on fingers / toes / other extemities, as it cuts off blood supply so effectively that the digit can be lost, so a tourniquet can be used as blood supply returns instantly when released.
 
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