Northerner
Admin (Retired)
- Relationship to Diabetes
- Type 1
Exome array genotyping, which allows focus on the protein coding regions of the genome, has enabled researchers to identify three new genes containing low-frequency variants that influence insulin levels.
The team also found low-frequency genetic variants in two genes known to be associated with fasting proinsulin concentrations.
"The exome array allowed us to test a large number of individuals - in this case, more than 8,000 people - very efficiently," said study author Karen Mohlke (University of North Carolina, Chapel Hill, USA) in a press statement.
In addition to allowing researchers to focus on coding regions of the genome, exome array analysis is also cheaper than more traditional genetic sequencing. "We expect that this type of analysis will be useful for finding low-frequency variants associated with many complex traits, including obesity or cancer," said Mohlke.
http://www.news-medical.net/news/20130107/New-insulin-associated-genetic-variants-discovered.aspx
The team also found low-frequency genetic variants in two genes known to be associated with fasting proinsulin concentrations.
"The exome array allowed us to test a large number of individuals - in this case, more than 8,000 people - very efficiently," said study author Karen Mohlke (University of North Carolina, Chapel Hill, USA) in a press statement.
In addition to allowing researchers to focus on coding regions of the genome, exome array analysis is also cheaper than more traditional genetic sequencing. "We expect that this type of analysis will be useful for finding low-frequency variants associated with many complex traits, including obesity or cancer," said Mohlke.
http://www.news-medical.net/news/20130107/New-insulin-associated-genetic-variants-discovered.aspx