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Scientists report that they have identified the first compound that eliminates the ongoing degeneration of upper motor neurons that become diseased and are a key contributor to amyotrophic lateral sclerosis (ALS). The study was conducted at Northwestern University, US.
In ALS, movement-initiating nerve cells in the brain (upper motor neurons) and muscle-controlling nerve cells in the spinal cord (lower motor neurons) die. The disease results in rapidly progressing paralysis and death.
“Even though the upper motor neurons are responsible for the initiation and modulation of movement and their degeneration is an early event in ALS, so far there has been no treatment option to improve their health,” said senior author Associate Professor Hande Ozdinler. “We have identified the first compound that improves the health of upper motor neurons that become diseased.”
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In ALS, movement-initiating nerve cells in the brain (upper motor neurons) and muscle-controlling nerve cells in the spinal cord (lower motor neurons) die. The disease results in rapidly progressing paralysis and death.
“Even though the upper motor neurons are responsible for the initiation and modulation of movement and their degeneration is an early event in ALS, so far there has been no treatment option to improve their health,” said senior author Associate Professor Hande Ozdinler. “We have identified the first compound that improves the health of upper motor neurons that become diseased.”
Neuron damage from ALS reversed with new compound
Scientists have developed a compound that stops the degeneration of upper motor neurons, a contributor to ALS.
