Neural mast cell axis regulates skin microcirculation in diabetes

[Amity Island]

Changes in microcirculation lead to the progression of organ pathology in diabetes. Although neuroimmune interactions contribute to a variety of conditions, it is still unclear whether abnormal neural activities affect microcirculation related to diabetes. Using laser speckle contrast imaging, we examined the skin of patients with type 2 diabetes and found that their microvascular perfusion was significantly compromised.

A neural-mast cell axis regulates skin microcirculation in diabetes

Changes in microcirculation lead to the progression of organ pathology in diabetes. Although neuroimmune interactions contribute to a variety of conditions

diabetesjournals.org

 

[Skinny T2]

I wish I had done a few more years of science but I used ai to explain it to me like I am a 16 year old:
Sure, let's break this down in simpler terms:

The article talks about how problems with tiny blood vessels (microcirculation) can lead to organ damage in people with diabetes. Scientists aren't sure yet if unusual nerve activities are part of this problem.

To find out more, they used a special imaging technique to look at the skin of people with type 2 diabetes. They found that blood flow in these tiny vessels was much worse in these patients. They saw the same thing in mice that were fed a high-fat diet to mimic type 2 diabetes.

In both humans and mice, they noticed two types of immune cells in the skin: macrophages and mast cells. However, only the mast cells were necessary for the blood flow problems. These mast cells were activated by nerve cells with a specific receptor called TRPV1. When these nerves were very active, they caused the mast cells to release substances that messed up the blood flow.

They found that blocking these TRPV1 nerves improved blood flow in the skin. Another important discovery was about a molecule called Substance P (SP), which was found in higher amounts in the skin and nerves of people with type 2 diabetes. When they added extra SP, blood flow got worse, but when they blocked SP in the nerves, it stopped the mast cells from causing problems and improved blood flow.

In short, the study suggests that there's a connection between nerves and mast cells that affects blood flow in the skin of people with diabetes. This finding could help develop new treatments for diabetes-related problems.