N-glycan remodeling on glucagon receptor is an effector of nutrient-sensing by HBP

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Northerner

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Relationship to Diabetes
Type 1
A possible therapeutic target for control of blood glucose in the treatment of type 2 diabetes and obesity has been identified by Dr. Anita Johswich and her colleagues. Their findings were published in Journal of Biological Chemistry, online April 17, 2014.

An imbalance in the competing action of insulin and glucagon is widely viewed as a critical factor in onset of type 2 diabetes, a relentlessly increasing health problem. A delicate balance between two hormones controls blood glucose levels day and night. After a meal, blood glucose rises, which stimulates insulin release and promotes glucose uptake and metabolism. During periods of fasting the blood glucose drops and is countered by glucagon, which stimulates glucose synthesis (gluconeogenesis) to re-supply levels of circulating glucose.

http://phys.org/news/2014-04-n-glycan-remodeling-glucagon-receptor-effector.html
 
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