Mounjaro warning

[Taurean]

Hi , I’m new here, type 2 diabetes for 8 years. After my reading hit 10.8 my diabetic nurse suggested a trial of Mounjaro starting at 2.5 then after a month 5.0. On the lowest dose I felt worn out and really sickly ,my readings were up and down . On the 5 dose I felt dreadful , absolutely no interest in eating or drinking anything . Then I started to have familiar symptoms of two years ago to do with my kidneys, really bad pain, vommiting, erratic breathing and shivering . An ambulance was called and I’ve been in hospital for 6 days on various drips. I knew my symptoms were kidney stones which was confirmed but I now have AKI which I firmly believe was down to Mounjaro . Back in hospital next week to see if my kidney function has improved , I can’t have the op until they are stabilised . Whilst in hospital my diabetes reading was around 6.5 , now at home it’s 10.5 . After stopping Mounjaro I’m only on Metformin so this is probably the reason .

 

[John Gray]

Throughout this post, I should emphasise that "As always, your mileage may vary"...

I'm sorry to hear that you've had such trouble with Mounjaro. I only had problems with it when on the 7.5mg dose, where I completely lost any appetite, and had other side-effects like dizziness. Moving back to 5mg removed most associated problems.

I would 'check out' your firm belief that your AKI (Acute Kidney Injury?) was caused by Mounjaro with a renal specialist, but I don't find this listed anywhere in the possible side-effects. Gallstones, maybe. Coincidence?
Fortunately my own personal kidney stones have been dormant for over 15 years - I found that kidney stone pain was even more horrendous than man-flu!

If you have kidney problems there's a suggestion that you possibly shouldn't be on metformin (something else to check!).
Your eGFR values should be checked with a blood test - more renal specialist involvement.

Maybe consider insulin injections and / or something flozin-y, like epagliflozin, for your diabetes?

[Lots of checking involved here!]

 

[Taurean]

Thank you for taking the time to reply . The reason I suspect that Mounjaro was the cause of the ( yes , Acute Kidney Injury ) is that my bloods were checked only a week before starting the new med and were perfect . I’m a little worried as my GP has told me not to take any diabetes meds until the AKI is normalised then we will have a discussion . I was only on Metformin and the Mounjaro previous to this episode .
I hope your kidney stones remain dormant , I found my pain was worse than childbirth ! I’m apparently a stone former so I should expect this every few years , oh the joy !

 

[John Gray]

I am also a kidney stone former, or at least was.
They were rock-hard, so that even several lithotripsy sessions had minimal effect.
I had a large one removed via a percutaneous nephrolithotomy (twenty-or-so-years ago)!

If the doctor puts down your Acute Kidney Injury to Mounjaro, that really ought to be reported back via the Yellow Card system.

I hope you can be sorted out rapidly - maybe you need to be referred to a diabetes consultant at your local hospital, where much of the expertise is situated?

 

[everydayupsanddowns]

Thank you for taking the time to reply . The reason I suspect that Mounjaro was the cause of the ( yes , Acute Kidney Injury ) is that my bloods were checked only a week before starting the new med and were perfect . I’m a little worried as my GP has told me not to take any diabetes meds until the AKI is normalised then we will have a discussion

So sorry to hear about your Acute Kidney Injury @Taurean

Good to hear that you are well on the road to recovery now.

This looks to be the Mounjaro Patient Information Leaflet @John Gray - and it does mention the possibility of AKI under “Warnings and Precautions”

https://pi.lilly.com/us/mounjaro-uspi.pdf?s=pi

But yes perhaps flagging with the Yellow Card system would be worthwhile?