Missing Link Points to New Diabetes Target

[Northerner]

Scientists suggest that a protein known as thioredoxin-interacting protein (TXNIP) could represent a new target for diabetes and potentially other human diseases such as Wolfram syndrome that are associated with endoplasmic reticulum stress (ER stress). The researchers, headed by a University of Massachusetts (UMass) Medical School team, have found that TXNIP effectively triggers cell inflammatory responses as a result of ER stress caused by chronic high glucose levels, which leads directly to the death of insulin-producing β cells in the pancreas.

http://www.genengnews.com/gen-news-highlights/missing-link-points-to-new-diabetes-target/81247156/