Eddy Edson
Well-Known Member
- Relationship to Diabetes
- Type 2
A cat-amongst-the-pigeons new Mendelian randomisation study:
(Link to paper in the thread.)
Altogether, results of this study suggest that previously reported associations between the human gut microbiome and human disease might have been due to biases such as reverse causality or confounding and that the impact of the gut microbiota on cardiometabolic traits, chronic diseases and human longevity may not be as prominent as previously suggested ...
(The MR methods used in this study are supposed to reduce confounding and reverse causation risks, allowing for more robust inferences about causality.)
For human observational studies, multiple confounding factors could create spurious correlation between microbiome and chronic diseases, including antibiotic use, age, sex, diet, geography, BMI and alcohol intake [38]. Moreover, alteration of the gut microbiota could potentially be a consequence of disease states rather than a causal factor [14]. Altogether, the large proportion of null findings (i.e., human gut-related traits may not cause chronic disease) is in line with recent literature showing an overwhelming positive publication bias in the microbiome literature ...
(Link to paper in the thread.)
Altogether, results of this study suggest that previously reported associations between the human gut microbiome and human disease might have been due to biases such as reverse causality or confounding and that the impact of the gut microbiota on cardiometabolic traits, chronic diseases and human longevity may not be as prominent as previously suggested ...
(The MR methods used in this study are supposed to reduce confounding and reverse causation risks, allowing for more robust inferences about causality.)
For human observational studies, multiple confounding factors could create spurious correlation between microbiome and chronic diseases, including antibiotic use, age, sex, diet, geography, BMI and alcohol intake [38]. Moreover, alteration of the gut microbiota could potentially be a consequence of disease states rather than a causal factor [14]. Altogether, the large proportion of null findings (i.e., human gut-related traits may not cause chronic disease) is in line with recent literature showing an overwhelming positive publication bias in the microbiome literature ...
