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London woman off insulin for Type 1 diabetes after a single dose of experimental manufactured stem cells

Northerner

Admin (Retired)
Relationship to Diabetes
Type 1
Amanda Smith celebrates the day, August 1, nearly two years ago, when she stopped taking insulin to manage her type one diabetes, just a few months after getting a dose of experimental stem cells as part of a study.

“I remember, like, being scared and excited, and it’s history now,” she said.

The 36-year-old nurse and mother is part of a small, but what some call “milestone study,” of patients with Type 1 Diabetes using manufactured stem cells, designed to grow in the liver and become the full array of pancreatic islet cells that naturally control blood sugar levels.

In a study published in the New England Journal of Medicine, researchers report that of the 12 patients who received a single dose of the stem cells, it eliminated the need for insulin in 10 for at least a year and stopped episodes of low blood sugar, or hypoglycemia, which can lead to dangerous complications, even death. For Amanda, the treatment has been a blessing.


"Diagnosed with late-onset juvenile diabetes when she was 25" - erm, you can be diagnosed with T1D at any age, it's not 'late-onset juvenile diabetes' :( I was 49 and have known people in their 70s to receive a diagnosis :(
 
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There’s a lot of work going on with stem cells at the moment. Looks like there’s some interesting progress here.

The snag always seems to be maintaining the newly installed beta cells and protecting them from renewed autoimmune attack. Transplanted cells (like these stem cell ones) seem to only last about 5 years, even with immunosuppressants.

Still, great to see progress still being made!
 
Great results. I just hope they can find a way to eliminate the need for immunosuppressants very soon. The woman in the story was saying it was ‘just three pills a day’, but knowing someone who has to take them longterm, they can have nasty side effects. If only the beta cells can be ‘hidden’ somehow, then that would be fantastic.

Another thing I’ve always wondered is, what if they weren’t hidden and immunosuppressive wasn’t used - how quickly would the immune system kill them?
 
If only the beta cells can be ‘hidden’ somehow, then that would be fantastic.

Yes, some years ago I saw Prof John Pickup talking about progress in research into Nano-encapsulation at an INPUT thing (now absorbed into JDRF/Breakthrough T1). Ways of protecting implanted (or generated) beta cells have been a focus for research for some time. Still elusive though.
 
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